Adjunctive treatment in juvenile nasopharyngeal angiofibroma: How should we approach recurrence?

Daniel W Scholfield, Marie-Anne Brundler, Ann-Louise McDermott, Francis Mussai, Pamela Kearns

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
551 Downloads (Pure)

Abstract

A recent case of advanced, recurrent juvenile nasopharyngeal angiofibroma (JNA) at our institution has highlighted the limited evidence regarding adjunctive treatment. We present the case of a 10-year-old boy who is the first to undergo multiplestaged surgical resections alongside vincristine treatment. We performed a review of the literature analyzing the roles of radiation therapy, cytotoxic drugs, and novel targeted agents in JNA relapse. Small cohort studies suggest radiotherapy and flutamide are the most rational treatment options for residual and recurrent JNA. Our review highlights the need for further research into the management of primary and recurrent JNA.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalJournal of pediatric hematology/oncology
Volume38
Issue number3
DOIs
Publication statusPublished - 13 Apr 2016

Keywords

  • Dexamethasone
  • Flutamide
  • Juvenile nasopharyngeal angiofibroma
  • Radiotherapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Fingerprint

Dive into the research topics of 'Adjunctive treatment in juvenile nasopharyngeal angiofibroma: How should we approach recurrence?'. Together they form a unique fingerprint.

Cite this