Adaptive mutations produce resistance to ciprofloxacin

C Riesenfeld, M Everett, L J Piddock, B G Hall

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)


Mutation to ciprofloxacin resistance continually occurred in nondividing Escherichia coli cells during a 7-day exposure to ciprofloxacin in agar, while no accumulation of rifampin resistance mutations was detected in those cells. We propose that the resistance mutations result from adaptive mutations, which preferentially produce phenotypes that promote growth in nondividing cells.
Original languageEnglish
Pages (from-to)2059-60
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Issue number9
Publication statusPublished - Sept 1997


  • Adaptation, Physiological
  • Anti-Infective Agents
  • Ciprofloxacin
  • Escherichia coli
  • Microbial Sensitivity Tests
  • Mutation


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