Adaptive mutations produce resistance to ciprofloxacin

C Riesenfeld; M Everett; L J Piddock; B G Hall

Adaptive mutations produce resistance to ciprofloxacin

C Riesenfeld, M Everett, L J Piddock, B G Hall

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

Mutation to ciprofloxacin resistance continually occurred in nondividing Escherichia coli cells during a 7-day exposure to ciprofloxacin in agar, while no accumulation of rifampin resistance mutations was detected in those cells. We propose that the resistance mutations result from adaptive mutations, which preferentially produce phenotypes that promote growth in nondividing cells.

Original language	English
Pages (from-to)	2059-60
Number of pages	2
Journal	Antimicrobial Agents and Chemotherapy
Volume	41
Issue number	9
Publication status	Published - Sep 1997

Keywords

Adaptation, Physiological
Anti-Infective Agents
Ciprofloxacin
Escherichia coli
Microbial Sensitivity Tests
Mutation

Cite this

@article{f9a0a18a709d419898de8eba65ef1bfa,

title = "Adaptive mutations produce resistance to ciprofloxacin",

abstract = "Mutation to ciprofloxacin resistance continually occurred in nondividing Escherichia coli cells during a 7-day exposure to ciprofloxacin in agar, while no accumulation of rifampin resistance mutations was detected in those cells. We propose that the resistance mutations result from adaptive mutations, which preferentially produce phenotypes that promote growth in nondividing cells.",

keywords = "Adaptation, Physiological, Anti-Infective Agents, Ciprofloxacin, Escherichia coli, Microbial Sensitivity Tests, Mutation",

author = "C Riesenfeld and M Everett and Piddock, {L J} and Hall, {B G}",

year = "1997",

month = sep,

language = "English",

volume = "41",

pages = "2059--60",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "9",

}

TY - JOUR

T1 - Adaptive mutations produce resistance to ciprofloxacin

AU - Riesenfeld, C

AU - Everett, M

AU - Piddock, L J

AU - Hall, B G

PY - 1997/9

Y1 - 1997/9

N2 - Mutation to ciprofloxacin resistance continually occurred in nondividing Escherichia coli cells during a 7-day exposure to ciprofloxacin in agar, while no accumulation of rifampin resistance mutations was detected in those cells. We propose that the resistance mutations result from adaptive mutations, which preferentially produce phenotypes that promote growth in nondividing cells.

AB - Mutation to ciprofloxacin resistance continually occurred in nondividing Escherichia coli cells during a 7-day exposure to ciprofloxacin in agar, while no accumulation of rifampin resistance mutations was detected in those cells. We propose that the resistance mutations result from adaptive mutations, which preferentially produce phenotypes that promote growth in nondividing cells.

KW - Adaptation, Physiological

KW - Anti-Infective Agents

KW - Ciprofloxacin

KW - Escherichia coli

KW - Microbial Sensitivity Tests

KW - Mutation

M3 - Article

C2 - 9303418

VL - 41

SP - 2059

EP - 2060

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 9

ER -

Adaptive mutations produce resistance to ciprofloxacin

Abstract

Keywords

Fingerprint

Cite this