Acute simulated soccer-specific training increases PGC-1α mRNA expression in human skeletal muscle

T-S Jeong, JD Bartlett, C-H Joo, J Louhelainen, Graeme L. Close, JP Morton, B Drust

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The aim of the current study was to quantify oxygen uptake, heart rate and molecular responses of human skeletal muscle associated with mitochondrial biogenesis following an acute bout of simulated soccer training. Muscle biopsies (vastus lateralis) were obtained from nine active men immediately pre-completion, post-completion and 3 h post-completion of a laboratory-based soccer-specific training simulation on a motorised treadmill. The soccer-specific simulation was a similar intensity (55 ± 6% V.O2 max) and duration (60 min) as that observed in professional soccer training (e.g. standing 41%, walking 37%, jogging 11%, high-speed running 9% and sprinting 2%). Post-exercise, muscle glycogen decreased (Pre; 397 ± 86 mmol∙kg−1 dw, Post; 344 ± 64 mmol∙kg−1 dw; P = 0.03), plasma lactate increased (P < 0.001) up to ~4–5 mmol∙L−1, non-esterified fatty acids and glycerol increased (P < 0.001) to values of 0.6 ± 0.2 mmol∙L−1 and 145 ± 54 μmol∙L−1, respectively. PGC-1α mRNA increased (P = 0.009) fivefold 3 h post-exercise. We provide novel data by demonstrating that soccer-specific training is associated with increases in PGC-1α mRNA. These data may have implications for practitioners in better understanding the metabolic and muscle responses to soccer-specific training protocols in the field.
Original languageEnglish
Pages (from-to)1493-1503
Number of pages11
JournalJournal of Sports Sciences
Issue number14
Early online date23 Dec 2014
Publication statusPublished - 2015


  • intermittent exercise
  • vastus lateralis
  • cell signalling


Dive into the research topics of 'Acute simulated soccer-specific training increases PGC-1α mRNA expression in human skeletal muscle'. Together they form a unique fingerprint.

Cite this