Activity of 13 beta-lactam agents combined with BRL 42715 against beta-lactamase producing gram-negative bacteria compared to combinations with clavulanic acid, tazobactam and sulbactam

L J Piddock, Y F Jin, H L Turner

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The activity of six cephalosporins, six penicillins and one monobactam combined with BRL 42715, clavulanic acid, sulbactam or tazobactam at 0.1, 0.5, 1, 2, 5 and 10 mg/L was determined for 45 beta-lactamase producing Gram-negative bacteria. The combination of BRL 42715 with any of the agents was more active than any of the other inhibitor and beta-lactam combinations. Unlike the other beta-lactamase inhibitors, BRL 42715 enhanced the activity of the beta-lactams for strains that constitutively expressed Richmond & Sykes Class I beta-lactamase and against strains expressing extended-spectrum plasmid-mediated beta-lactamases.
Original languageEnglish
Pages (from-to)89-103
Number of pages15
JournalJournal of Antimicrobial Chemotherapy
Volume31
Issue number1
Publication statusPublished - Jan 1993

Keywords

  • Anti-Bacterial Agents
  • Clavulanic Acid
  • Clavulanic Acids
  • Drug Therapy, Combination
  • Enzyme Inhibitors
  • Gram-Negative Bacteria
  • Lactams
  • Penicillanic Acid
  • Sulbactam
  • beta-Lactamases
  • beta-Lactams

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