Achalasia is associated with atopy in patients under 40 years of age

Dominic King; Tom Thomas; Joht Singh Chandan; Nij  Bhala; Nicola Adderley; Krishnarajah Nirantharakumar; Nigel Trudgill

Achalasia is associated with atopy in patients under 40 years of age

Dominic King, Tom Thomas, Joht Singh Chandan, Nij Bhala, Nicola Adderley, Krishnarajah Nirantharakumar, Nigel Trudgill

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Abstract

Introduction: Case reports describe individuals with achalasia features subsequently diagnosed with eosinophilic esophagitis (an atopic disorder). We have examined associations between achalasia and atopic and autoimmune conditions. Methods: UK cohort study of 2,593 subjects with achalasia, matched to 10,402 controls. Results: At diagnosis, achalasia was associated with autoimmune conditions (odds ratio 1.39; 95%CI 1.02-1.90) and atopic conditions (1.40; 1.00-1.95) conditions in those aged <40. Conclusions: Our findings support an autoimmune aetiology in achalasia but also suggest a possible atopic aetiology in younger subjects.

Original language	English
Journal	The American Journal of Gastroenterology
Publication status	Accepted/In press - 21 Sept 2020

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title = "Achalasia is associated with atopy in patients under 40 years of age",

abstract = "Introduction: Case reports describe individuals with achalasia features subsequently diagnosed with eosinophilic esophagitis (an atopic disorder). We have examined associations between achalasia and atopic and autoimmune conditions. Methods: UK cohort study of 2,593 subjects with achalasia, matched to 10,402 controls. Results: At diagnosis, achalasia was associated with autoimmune conditions (odds ratio 1.39; 95%CI 1.02-1.90) and atopic conditions (1.40; 1.00-1.95) conditions in those aged <40. Conclusions: Our findings support an autoimmune aetiology in achalasia but also suggest a possible atopic aetiology in younger subjects. ",

author = "Dominic King and Tom Thomas and Chandan, {Joht Singh} and Nij Bhala and Nicola Adderley and Krishnarajah Nirantharakumar and Nigel Trudgill",

year = "2020",

month = sep,

day = "21",

language = "English",

journal = "The American Journal of Gastroenterology",

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T1 - Achalasia is associated with atopy in patients under 40 years of age

AU - King, Dominic

AU - Thomas, Tom

AU - Chandan, Joht Singh

AU - Bhala, Nij

AU - Adderley, Nicola

AU - Nirantharakumar, Krishnarajah

AU - Trudgill, Nigel

PY - 2020/9/21

Y1 - 2020/9/21

N2 - Introduction: Case reports describe individuals with achalasia features subsequently diagnosed with eosinophilic esophagitis (an atopic disorder). We have examined associations between achalasia and atopic and autoimmune conditions. Methods: UK cohort study of 2,593 subjects with achalasia, matched to 10,402 controls. Results: At diagnosis, achalasia was associated with autoimmune conditions (odds ratio 1.39; 95%CI 1.02-1.90) and atopic conditions (1.40; 1.00-1.95) conditions in those aged <40. Conclusions: Our findings support an autoimmune aetiology in achalasia but also suggest a possible atopic aetiology in younger subjects.

AB - Introduction: Case reports describe individuals with achalasia features subsequently diagnosed with eosinophilic esophagitis (an atopic disorder). We have examined associations between achalasia and atopic and autoimmune conditions. Methods: UK cohort study of 2,593 subjects with achalasia, matched to 10,402 controls. Results: At diagnosis, achalasia was associated with autoimmune conditions (odds ratio 1.39; 95%CI 1.02-1.90) and atopic conditions (1.40; 1.00-1.95) conditions in those aged <40. Conclusions: Our findings support an autoimmune aetiology in achalasia but also suggest a possible atopic aetiology in younger subjects.

M3 - Article

SN - 0002-9270

JO - The American Journal of Gastroenterology

JF - The American Journal of Gastroenterology

ER -

Achalasia is associated with atopy in patients under 40 years of age

Abstract

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