Achalasia is associated with atopy in patients under 40 years of age

Dominic King, Tom Thomas, Joht Singh Chandan, Nij Bhala, Nicola Adderley, Krishnarajah Nirantharakumar, Nigel Trudgill

Research output: Contribution to journalArticlepeer-review


Introduction: Case reports describe individuals with achalasia features subsequently diagnosed with eosinophilic esophagitis (an atopic disorder). We have examined associations between achalasia and atopic and autoimmune conditions. Methods: UK cohort study of 2,593 subjects with achalasia, matched to 10,402 controls. Results: At diagnosis, achalasia was associated with autoimmune conditions (odds ratio 1.39; 95%CI 1.02-1.90) and atopic conditions (1.40; 1.00-1.95) conditions in those aged <40. Conclusions: Our findings support an autoimmune aetiology in achalasia but also suggest a possible atopic aetiology in younger subjects.
Original languageEnglish
JournalThe American Journal of Gastroenterology
Publication statusAccepted/In press - 21 Sept 2020


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