ACE I/D polymorphism is a risk factor of Alzheimer's disease, but not of vascular dementia

H Kolsch; F Jessen; N Freymann; M Kreis; F Hentschel; W Maier; Reinhard Heun

doi:10.1016/j.neulet.2004.11.062

ACE I/D polymorphism is a risk factor of Alzheimer's disease, but not of vascular dementia

H Kolsch, F Jessen, N Freymann, M Kreis, F Hentschel, W Maier, Reinhard Heun

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Abstract

Different studies have investigated the effect of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the risk of Alzheimer dementia (AD). However, results on the association of the ACE-I allele with AD have been inconclusive. A recent meta-analysis reported an association of the I-allele with the risk of AD. A few small studies also investigated the effect of ACE polymorphism on the risk of vascular dementia (VD). We have investigated the effect of ACE I/D polymorphism in 351 AD and 155 VD patients and 348 healthy controls. We found the I/I genotype to be associated with an increased risk of AD, but not with the risk of VD. Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD.

Original language	English
Pages (from-to)	37-39
Number of pages	3
Journal	Neuroscience Letters
Volume	377
DOIs	https://doi.org/10.1016/j.neulet.2004.11.062
Publication status	Published - 22 Mar 2005

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title = "ACE I/D polymorphism is a risk factor of Alzheimer's disease, but not of vascular dementia",

abstract = "Different studies have investigated the effect of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the risk of Alzheimer dementia (AD). However, results on the association of the ACE-I allele with AD have been inconclusive. A recent meta-analysis reported an association of the I-allele with the risk of AD. A few small studies also investigated the effect of ACE polymorphism on the risk of vascular dementia (VD). We have investigated the effect of ACE I/D polymorphism in 351 AD and 155 VD patients and 348 healthy controls. We found the I/I genotype to be associated with an increased risk of AD, but not with the risk of VD. Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD.",

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T1 - ACE I/D polymorphism is a risk factor of Alzheimer's disease, but not of vascular dementia

AU - Kolsch, H

AU - Jessen, F

AU - Freymann, N

AU - Kreis, M

AU - Hentschel, F

AU - Maier, W

AU - Heun, Reinhard

PY - 2005/3/22

Y1 - 2005/3/22

N2 - Different studies have investigated the effect of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the risk of Alzheimer dementia (AD). However, results on the association of the ACE-I allele with AD have been inconclusive. A recent meta-analysis reported an association of the I-allele with the risk of AD. A few small studies also investigated the effect of ACE polymorphism on the risk of vascular dementia (VD). We have investigated the effect of ACE I/D polymorphism in 351 AD and 155 VD patients and 348 healthy controls. We found the I/I genotype to be associated with an increased risk of AD, but not with the risk of VD. Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD.

AB - Different studies have investigated the effect of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the risk of Alzheimer dementia (AD). However, results on the association of the ACE-I allele with AD have been inconclusive. A recent meta-analysis reported an association of the I-allele with the risk of AD. A few small studies also investigated the effect of ACE polymorphism on the risk of vascular dementia (VD). We have investigated the effect of ACE I/D polymorphism in 351 AD and 155 VD patients and 348 healthy controls. We found the I/I genotype to be associated with an increased risk of AD, but not with the risk of VD. Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD.

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ACE I/D polymorphism is a risk factor of Alzheimer's disease, but not of vascular dementia

Abstract

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