Accuracy of fibronectin tests for the prediction of pre-eclampsia: a systematic review

MMG Leeflang, JS Cnossen, JAM van der Post, BWJ Mol, Khalid Khan, Gerben ter Riet

Research output: Contribution to journalReview article

17 Citations (Scopus)


The purpose of this study was to review systematically all studies that assessed the accuracy of maternal plasma fibronectin as a serum marker for early prediction of pre-eclampsia. We therefore assessed studies that reported on fibronectin as serum marker for pre-eclampsia before the 25th gestational week. For the selected studies, sensitivity and specificity were calculated and plotted in ROC-space. We included 12 studies, of which only 5 studies reported sufficient data to calculate accuracy estimates, such as sensitivity and specificity. These five studies reported on 573 pregnant women of whom 109 developed pre-eclampsia. At a sensitivity of at least 50%, specificities ranged between 72 and 96% for cellular fibronectin. For total fibronectin, these numbers were 42-94%. Fibronectin seems to be a promising marker for the prediction of pre-eclampsia, however, further studies are needed to determine whether the accuracy of this test is sufficient to be clinically relevant. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)12-19
Number of pages8
JournalEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
Issue number1
Publication statusPublished - 1 Jul 2007


  • pre-eclampsia
  • prediction
  • fetal fibronectin
  • sensitivity and specificity
  • fibronectin


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