Absence of mutation in marRAB or soxRS in acrB-over expressing fluoroquinolone-resistant clinical and veterinary isolates of Escherichia coli

Mark Webber; Laura Piddock

doi:10.1128/AAC.45.5.1550-1552.2001

Absence of mutation in marRAB or soxRS in acrB-over expressing fluoroquinolone-resistant clinical and veterinary isolates of Escherichia coli

Mark Webber, Laura Piddock

Immunology and Immunotherapy

Research output: Contribution to journal › Article

87 Citations (Scopus)

Abstract

The amount of acrB, marA, and soxS mRNA was determined in 36 fluoroquinolone-resistant E. coli from humans and animals, 27 of which displayed a multiple-resistance phenotype. acrB mRNA was elevated in 11 of 36 strains. A mutation at codon 45 (Arg-->Cys) in acrR was found in 6 of these 11 strains. Ten of the 36 isolates appeared to overexpress soxS, and five appeared to overexpress marA. A number of mutations were found in the marR and soxR repressor genes, correlating with greater amounts of marA and soxS mRNA, respectively.

Original language	English
Pages (from-to)	1550-2
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	45
Issue number	5
DOIs	https://doi.org/10.1128/AAC.45.5.1550-1552.2001
Publication status	Published - 1 May 2001

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title = "Absence of mutation in marRAB or soxRS in acrB-over expressing fluoroquinolone-resistant clinical and veterinary isolates of Escherichia coli",

abstract = "The amount of acrB, marA, and soxS mRNA was determined in 36 fluoroquinolone-resistant E. coli from humans and animals, 27 of which displayed a multiple-resistance phenotype. acrB mRNA was elevated in 11 of 36 strains. A mutation at codon 45 (Arg-->Cys) in acrR was found in 6 of these 11 strains. Ten of the 36 isolates appeared to overexpress soxS, and five appeared to overexpress marA. A number of mutations were found in the marR and soxR repressor genes, correlating with greater amounts of marA and soxS mRNA, respectively.",

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N2 - The amount of acrB, marA, and soxS mRNA was determined in 36 fluoroquinolone-resistant E. coli from humans and animals, 27 of which displayed a multiple-resistance phenotype. acrB mRNA was elevated in 11 of 36 strains. A mutation at codon 45 (Arg-->Cys) in acrR was found in 6 of these 11 strains. Ten of the 36 isolates appeared to overexpress soxS, and five appeared to overexpress marA. A number of mutations were found in the marR and soxR repressor genes, correlating with greater amounts of marA and soxS mRNA, respectively.

AB - The amount of acrB, marA, and soxS mRNA was determined in 36 fluoroquinolone-resistant E. coli from humans and animals, 27 of which displayed a multiple-resistance phenotype. acrB mRNA was elevated in 11 of 36 strains. A mutation at codon 45 (Arg-->Cys) in acrR was found in 6 of these 11 strains. Ten of the 36 isolates appeared to overexpress soxS, and five appeared to overexpress marA. A number of mutations were found in the marR and soxR repressor genes, correlating with greater amounts of marA and soxS mRNA, respectively.

UR - https://www.scopus.com/pages/publications/0035032566

U2 - 10.1128/AAC.45.5.1550-1552.2001

DO - 10.1128/AAC.45.5.1550-1552.2001

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

Absence of mutation in marRAB or soxRS in acrB-over expressing fluoroquinolone-resistant clinical and veterinary isolates of Escherichia coli

Abstract

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