TY - JOUR
T1 - Absence of mutation in marRAB or soxRS in acrB-over expressing fluoroquinolone-resistant clinical and veterinary isolates of Escherichia coli
AU - Webber, Mark
AU - Piddock, Laura
PY - 2001/5/1
Y1 - 2001/5/1
N2 - The amount of acrB, marA, and soxS mRNA was determined in 36 fluoroquinolone-resistant E. coli from humans and animals, 27 of which displayed a multiple-resistance phenotype. acrB mRNA was elevated in 11 of 36 strains. A mutation at codon 45 (Arg-->Cys) in acrR was found in 6 of these 11 strains. Ten of the 36 isolates appeared to overexpress soxS, and five appeared to overexpress marA. A number of mutations were found in the marR and soxR repressor genes, correlating with greater amounts of marA and soxS mRNA, respectively.
AB - The amount of acrB, marA, and soxS mRNA was determined in 36 fluoroquinolone-resistant E. coli from humans and animals, 27 of which displayed a multiple-resistance phenotype. acrB mRNA was elevated in 11 of 36 strains. A mutation at codon 45 (Arg-->Cys) in acrR was found in 6 of these 11 strains. Ten of the 36 isolates appeared to overexpress soxS, and five appeared to overexpress marA. A number of mutations were found in the marR and soxR repressor genes, correlating with greater amounts of marA and soxS mRNA, respectively.
UR - http://www.scopus.com/inward/record.url?scp=0035032566&partnerID=8YFLogxK
U2 - 10.1128/AAC.45.5.1550-1552.2001
DO - 10.1128/AAC.45.5.1550-1552.2001
M3 - Article
C2 - 11302826
VL - 45
SP - 1550
EP - 1552
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 5
ER -