Absence of exercise-induced leptin suppression associated with insufficient epinephrine reserve in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency

F G Riepe; N Krone; S N Krüger; F C G J Sweep; J W M Lenders; J Dötsch; H Mönig; W G Sippell; C-J Partsch

doi:10.1055/s-2005-865836

Absence of exercise-induced leptin suppression associated with insufficient epinephrine reserve in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency

F G Riepe, N Krone, S N Krüger, F C G J Sweep, J W M Lenders, J Dötsch, H Mönig, W G Sippell, C-J Partsch

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19 Citations (Scopus)

Abstract

Patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency suffer from glucocorticoid and mineralocorticoid deficiency. They have insufficient epinephrine reserves and increased basal leptin levels and are often insulin resistant. In healthy subjects, an inhibitory effect of acute catecholamine elevation on the leptin plasma concentrations has been reported. However, it is not yet known how leptin levels respond to exercise in CAH patients.

Original language	English
Pages (from-to)	105-10
Number of pages	6
Journal	Experimental and Clinical Endocrinology and Diabetes
Volume	114
Issue number	3
DOIs	https://doi.org/10.1055/s-2005-865836
Publication status	Published - 2006

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Riepe, F. G., Krone, N., Krüger, S. N., Sweep, F. C. G. J., Lenders, J. W. M., Dötsch, J., Mönig, H., Sippell, W. G., & Partsch, C.-J. (2006). Absence of exercise-induced leptin suppression associated with insufficient epinephrine reserve in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Experimental and Clinical Endocrinology and Diabetes, 114(3), 105-10. https://doi.org/10.1055/s-2005-865836

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abstract = "Patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency suffer from glucocorticoid and mineralocorticoid deficiency. They have insufficient epinephrine reserves and increased basal leptin levels and are often insulin resistant. In healthy subjects, an inhibitory effect of acute catecholamine elevation on the leptin plasma concentrations has been reported. However, it is not yet known how leptin levels respond to exercise in CAH patients.",

author = "Riepe, {F G} and N Krone and Kr{\"u}ger, {S N} and Sweep, {F C G J} and Lenders, {J W M} and J D{\"o}tsch and H M{\"o}nig and Sippell, {W G} and C-J Partsch",

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Riepe, FG, Krone, N, Krüger, SN, Sweep, FCGJ, Lenders, JWM, Dötsch, J, Mönig, H, Sippell, WG & Partsch, C-J 2006, 'Absence of exercise-induced leptin suppression associated with insufficient epinephrine reserve in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency', Experimental and Clinical Endocrinology and Diabetes, vol. 114, no. 3, pp. 105-10. https://doi.org/10.1055/s-2005-865836

Absence of exercise-induced leptin suppression associated with insufficient epinephrine reserve in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. / Riepe, F G; Krone, N; Krüger, S N et al.
In: Experimental and Clinical Endocrinology and Diabetes, Vol. 114, No. 3, 2006, p. 105-10.

Research output: Contribution to journal › Article › peer-review

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AU - Sippell, W G

AU - Partsch, C-J

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AB - Patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency suffer from glucocorticoid and mineralocorticoid deficiency. They have insufficient epinephrine reserves and increased basal leptin levels and are often insulin resistant. In healthy subjects, an inhibitory effect of acute catecholamine elevation on the leptin plasma concentrations has been reported. However, it is not yet known how leptin levels respond to exercise in CAH patients.

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Absence of exercise-induced leptin suppression associated with insufficient epinephrine reserve in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Abstract

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