TY - JOUR
T1 - Abnormal circulating levels of metalloprotease 9 and its tissue inhibitor 1 in angiographically proven peripheral arterial disease: relationship to disease severity
AU - Tayebjee, Muzahir
AU - Tan, KT
AU - Macfadyen, Robert
AU - Lip, Gregory
PY - 2005/1/1
Y1 - 2005/1/1
N2 - BACKGROUND: Peripheral arterial disease (PAD) is associated with adaptive changes in the vascular and muscle extracellular matrix (ECM) in response to reduced blood flow. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), are key modulators of ECM turnover. We hypothesized that patients with intermittent claudication (with low ankle-brachial blood pressure index,
AB - BACKGROUND: Peripheral arterial disease (PAD) is associated with adaptive changes in the vascular and muscle extracellular matrix (ECM) in response to reduced blood flow. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), are key modulators of ECM turnover. We hypothesized that patients with intermittent claudication (with low ankle-brachial blood pressure index,
U2 - 10.1111/j.1365-2796.2004.01431.x
DO - 10.1111/j.1365-2796.2004.01431.x
M3 - Article
C2 - 15606382
SN - 1365-2796
VL - 257
SP - 110
EP - 116
JO - Journal of Internal Medicine
JF - Journal of Internal Medicine
IS - 1
ER -