Abnormal circulating levels of metalloprotease 9 and its tissue inhibitor 1 in angiographically proven peripheral arterial disease: relationship to disease severity

Muzahir Tayebjee, KT Tan, Robert Macfadyen, Gregory Lip

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

BACKGROUND: Peripheral arterial disease (PAD) is associated with adaptive changes in the vascular and muscle extracellular matrix (ECM) in response to reduced blood flow. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), are key modulators of ECM turnover. We hypothesized that patients with intermittent claudication (with low ankle-brachial blood pressure index,
Original languageEnglish
Pages (from-to)110-6
Number of pages7
JournalJournal of Internal Medicine
Volume257
Issue number1
DOIs
Publication statusPublished - 1 Jan 2005

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