A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

David Reich, Nick Patterson, Philip L De Jager, Gavin J McDonald, Alicja Waliszewska, Arti Tandon, Robin R Lincoln, Cari DeLoa, Scott A Fruhan, Philippe Cabre, Odile Bera, Gilbert Semana, M Ann Kelly, David A Francis, Kristin Ardlie, Omar Khan, Bruce A C Cree, Stephen L Hauser, Jorge R Oksenberg, David A HaflerMarilyn Kelly

Research output: Contribution to journalArticlepeer-review

221 Citations (Scopus)


Multiple sclerosis is a common disease with proven heritability, but, despite large-scale attempts, no underlying risk genes have been identified. Traditional linkage scans have so far identified only one risk haplotype for multiple sclerosis (at HLA on chromosome 6), which explains only a fraction of the increased risk to siblings. Association scans such as admixture mapping have much more power, in principle, to find the weak factors that must explain most of the disease risk. We describe here the first high-powered admixture scan, focusing on 605 African American cases and 1,043 African American controls, and report a locus on chromosome 1 that is significantly associated with multiple sclerosis.
Original languageEnglish
Pages (from-to)1113-8
Number of pages6
JournalNature Genetics
Issue number10
Publication statusPublished - 2005


Dive into the research topics of 'A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility'. Together they form a unique fingerprint.

Cite this