Projects per year
Abstract
Lysozymes are antimicrobial enzymes that perform a critical role in resisting infection in a wide-range of eukaryotes. However, using the nematode Caenorhabditis elegans as a model host we now demonstrate that deletion of the protist type lysozyme LYS-7 renders animals susceptible to killing by the fatal fungal human pathogen Cryptococcus neoformans, but, remarkably, enhances tolerance to the enteric bacteria Salmonella Typhimurium. This trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously thought.
Original language | English |
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Pages (from-to) | e16839 |
Journal | PLoS ONE |
Volume | 6 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Jan 2011 |
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Dive into the research topics of 'A two-gene balance regulates salmonella typhimurium tolerance in the nematode Caenorhabditis elegans.'. Together they form a unique fingerprint.Projects
- 2 Finished
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The role of DAF-16 in driving the evolution of immunity mechanisms in nematodes
May, R. (Principal Investigator)
Biotechnology & Biological Sciences Research Council
1/04/08 → 31/03/11
Project: Research Councils
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Identifying the mechanism of intracellular parasitism by Cryptococcus
May, R. (Principal Investigator)
1/10/07 → 30/09/10
Project: Research Councils