Recent advances in tridimensional (3D) tissue imaging have considerably enriched our view of the pituitary gland and its development. Whereas traditional histology of the pituitary anterior lobe portrayed this tissue as a patchwork of cells, 3D imaging revealed that cells of each lineage form extensive and structured homotypic networks. In the adult gland these networks contribute to the robustness and coordination of the cell response to secretagogs. In addition, the network organization adapts to changes in endocrine environment, as revealed by the sexually dimorphic growth hormone (GH) cell network. Further work is required to establish better the molecular basis for homotypic and heterotypic interactions in the pituitary as well as the implications of these interactions for pituitary function and dysfunction in humans.
|Number of pages||9|
|Journal||Trends in Endocrinology and Metabolism|
|Publication status||Published - Jun 2012|
Bibliographical noteCopyright © 2012 Elsevier Ltd. All rights reserved.
- Cell Communication
- Cell Differentiation
- Imaging, Three-Dimensional
- Pituitary Gland
- Pituitary Gland, Anterior
- Signal Transduction