A thyroxine absorption test followed by weekly thyroxine administration: a method to assess non-adherence to treatment

J N Walker, P Shillo, V Ibbotson, A Vincent, N Karavitaki, A P Weetman, J A H Wass, A Allahabadia

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


OBJECTIVE: For patients who remain hypothyroid despite the administration of what would seem adequate doses of levothyroxine (L-T4), the underlying cause can be difficult to determine. The possibility of a biological cause should first be explored; however, in the majority of cases, poor adherence to medication is likely to be the main cause of treatment failure. When non-adherence is suspected but not volunteered, options to confirm the suspicion are limited. In this study, we identified patients for whom known drugs and pathological causes of L-T4 malabsorption were excluded, and despite often high doses of L-T4, the patients remained hypothyroid.

DESIGN: Using a weight-determined oral L-T4 bolus administration, absorption was initially assessed in 23 patients. In nearly all patients, this was shown to be maximal at 120 min post-ingestion. This was then followed by the continued administration of a weekly T4 bolus for a 4-week period after which TSH and free T4 (fT4) levels were recorded.

RESULTS: All patients showed a rise in fT4 at 120 min following the administration of the L-T4 bolus, with a mean increase of 54±3% from baseline. Following the treatment period, using an equivalent weekly L-T4 dose, which was significantly less than that of the daily dose taken by the patients before the test, TSH reduced from baseline in ~75% of cases.

CONCLUSION: Using this combination of tests allows significant malabsorptive problems to be identified first and then potential non-adherence to be demonstrated. A management plan can then be implemented to increase adherence, aiming to improve treatment outcomes.

Original languageEnglish
Pages (from-to)913-7
Number of pages5
JournalEuropean Journal of Endocrinology
Issue number6
Publication statusPublished - Jun 2013


  • Adult
  • Aged
  • Aged, 80 and over
  • Drug Administration Schedule
  • Female
  • Humans
  • Male
  • Middle Aged
  • Thyrotropin
  • Thyroxine
  • Young Adult


Dive into the research topics of 'A thyroxine absorption test followed by weekly thyroxine administration: a method to assess non-adherence to treatment'. Together they form a unique fingerprint.

Cite this