A study of T cell tolerance to the tumor-associated antigen MDM2: cytokines can restore antigen responsiveness, but not high avidity T cell function

Gavin M Bendle; Shao-An Xue; Angelika Holler; Hans J Stauss

doi:10.1371/journal.pone.0000353

A study of T cell tolerance to the tumor-associated antigen MDM2: cytokines can restore antigen responsiveness, but not high avidity T cell function

Gavin M Bendle, Shao-An Xue, Angelika Holler, Hans J Stauss

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Most tumor-associated antigens (TAA) currently used for immunotherapy of cancer are also expressed in normal tissues, which may induce tolerance and impair T cell-mediated immunity. However, there is limited information about how physiological expression in normal tissues alters the function of TAA-specific T cells.

Original language	English
Pages (from-to)	e353
Journal	PLoS ONE
Volume	2
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0000353
Publication status	Published - 2007

Keywords

Animals
Antibody Affinity
Base Sequence
Cell Differentiation
Cell Proliferation
Cytokines
DNA Primers
Flow Cytometry
Immune Tolerance
Mice
Mice, Transgenic
Polymerase Chain Reaction
Proto-Oncogene Proteins c-mdm2
T-Lymphocytes, Cytotoxic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1371/journal.pone.0000353

Cite this

@article{9e9e2f0307ae4db2bcf74fe93cad99e2,

title = "A study of T cell tolerance to the tumor-associated antigen MDM2: cytokines can restore antigen responsiveness, but not high avidity T cell function",

abstract = "Most tumor-associated antigens (TAA) currently used for immunotherapy of cancer are also expressed in normal tissues, which may induce tolerance and impair T cell-mediated immunity. However, there is limited information about how physiological expression in normal tissues alters the function of TAA-specific T cells.",

keywords = "Animals, Antibody Affinity, Base Sequence, Cell Differentiation, Cell Proliferation, Cytokines, DNA Primers, Flow Cytometry, Immune Tolerance, Mice, Mice, Transgenic, Polymerase Chain Reaction, Proto-Oncogene Proteins c-mdm2, T-Lymphocytes, Cytotoxic",

author = "Bendle, \{Gavin M\} and Shao-An Xue and Angelika Holler and Stauss, \{Hans J\}",

year = "2007",

doi = "10.1371/journal.pone.0000353",

language = "English",

volume = "2",

pages = "e353",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science (PLOS)",

number = "4",

}

TY - JOUR

T1 - A study of T cell tolerance to the tumor-associated antigen MDM2

T2 - cytokines can restore antigen responsiveness, but not high avidity T cell function

AU - Bendle, Gavin M

AU - Xue, Shao-An

AU - Holler, Angelika

AU - Stauss, Hans J

PY - 2007

Y1 - 2007

N2 - Most tumor-associated antigens (TAA) currently used for immunotherapy of cancer are also expressed in normal tissues, which may induce tolerance and impair T cell-mediated immunity. However, there is limited information about how physiological expression in normal tissues alters the function of TAA-specific T cells.

AB - Most tumor-associated antigens (TAA) currently used for immunotherapy of cancer are also expressed in normal tissues, which may induce tolerance and impair T cell-mediated immunity. However, there is limited information about how physiological expression in normal tissues alters the function of TAA-specific T cells.

KW - Animals

KW - Antibody Affinity

KW - Base Sequence

KW - Cell Differentiation

KW - Cell Proliferation

KW - Cytokines

KW - DNA Primers

KW - Flow Cytometry

KW - Immune Tolerance

KW - Mice

KW - Mice, Transgenic

KW - Polymerase Chain Reaction

KW - Proto-Oncogene Proteins c-mdm2

KW - T-Lymphocytes, Cytotoxic

U2 - 10.1371/journal.pone.0000353

DO - 10.1371/journal.pone.0000353

M3 - Article

C2 - 17406677

SN - 1932-6203

VL - 2

SP - e353

JO - PLoS ONE

JF - PLoS ONE

IS - 4

ER -

A study of T cell tolerance to the tumor-associated antigen MDM2: cytokines can restore antigen responsiveness, but not high avidity T cell function

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this