A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

Batika M. J. Rana; Eric Jou; Jillian L. Barlow; Noe Rodriguez-Rodriguez; Jennifer A. Walker; Claire Knox; Helen E. Jolin; Clare S. Hardman; Meera Sivasubramaniam; Aydan Szeto; E. Suzanne Cohen; Ian C. Scott; Matthew A. Sleeman; Chiamaka I. Chidomere; Sara Cruz Migoni; Jorge Caamano; Helle F. Jorgensen; Stefania Carobbio; Antonio Vidal-Puig; Andrew N. J. McKenzie

doi:10.1084/jem.20190689

A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

Batika M. J. Rana, Eric Jou, Jillian L. Barlow, Noe Rodriguez-Rodriguez, Jennifer A. Walker, Claire Knox, Helen E. Jolin, Clare S. Hardman, Meera Sivasubramaniam, Aydan Szeto, E. Suzanne Cohen, Ian C. Scott, Matthew A. Sleeman, Chiamaka I. Chidomere, Sara Cruz Migoni, Jorge Caamano, Helle F. Jorgensen, Stefania Carobbio, Antonio Vidal-Puig, Andrew N. J. McKenzie^*

^*Corresponding author for this work

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

261 Downloads (Pure)

Abstract

Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1-mediated proliferation and activation of LFA-1-expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT.

Original language	English
Pages (from-to)	1999-2009
Number of pages	11
Journal	The Journal of Experimental Medicine
Volume	216
Issue number	9
Early online date	27 Jun 2019
DOIs	https://doi.org/10.1084/jem.20190689
Publication status	Published - 2 Sept 2019

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1084/jem.20190689Licence: Creative Commons: Attribution (CC BY)

Rana_et_al_A-stromal_cell_niche_Journal_of_Experimental_Medicine_2019
Checked for eligibility: 10/07/2019 A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue. Batika M.J. Rana, Eric Jou, Jillian L. Barlow, Noe Rodriguez-Rodriguez, Jennifer A. Walker, Claire Knox, Helen E. Jolin, Clare S. Hardman, Meera Sivasubramaniam, Aydan Szeto, E. Suzanne Cohen, Ian C. Scott, Matthew A. Sleeman, Chiamaka I. Chidomere, Sara Cruz Migoni, Jorge Caamano, Helle F. Jorgensen, Stefania Carobbio, Antonio Vidal-Puig, Andrew N.J. McKenzie. Journal of Experimental Medicine Jun 2019, jem.20190689; DOI: 10.1084/jem.20190689
Final published version, 2.55 MBLicence: Creative Commons: Attribution (CC BY)

http://jem.rupress.org/content/216/9/1999Licence: Creative Commons: Attribution (CC BY)

Cite this

Rana, B. M. J., Jou, E., Barlow, J. L., Rodriguez-Rodriguez, N., Walker, J. A., Knox, C., Jolin, H. E., Hardman, C. S., Sivasubramaniam, M., Szeto, A., Cohen, E. S., Scott, I. C., Sleeman, M. A., Chidomere, C. I., Cruz Migoni, S., Caamano, J., Jorgensen, H. F., Carobbio, S., Vidal-Puig, A., & McKenzie, A. N. J. (2019). A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue. The Journal of Experimental Medicine, 216(9), 1999-2009. https://doi.org/10.1084/jem.20190689

@article{a3855aa6a8a84fd58fb4294955ba3d42,

title = "A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue",

abstract = "Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1-mediated proliferation and activation of LFA-1-expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT.",

author = "Rana, {Batika M. J.} and Eric Jou and Barlow, {Jillian L.} and Noe Rodriguez-Rodriguez and Walker, {Jennifer A.} and Claire Knox and Jolin, {Helen E.} and Hardman, {Clare S.} and Meera Sivasubramaniam and Aydan Szeto and Cohen, {E. Suzanne} and Scott, {Ian C.} and Sleeman, {Matthew A.} and Chidomere, {Chiamaka I.} and {Cruz Migoni}, Sara and Jorge Caamano and Jorgensen, {Helle F.} and Stefania Carobbio and Antonio Vidal-Puig and McKenzie, {Andrew N. J.}",

year = "2019",

month = sep,

day = "2",

doi = "10.1084/jem.20190689",

language = "English",

volume = "216",

pages = "1999--2009",

journal = "The Journal of Experimental Medicine",

issn = "0022-1007",

publisher = "Rockefeller University Press",

number = "9",

}

Rana, BMJ, Jou, E, Barlow, JL, Rodriguez-Rodriguez, N, Walker, JA, Knox, C, Jolin, HE, Hardman, CS, Sivasubramaniam, M, Szeto, A, Cohen, ES, Scott, IC, Sleeman, MA, Chidomere, CI, Cruz Migoni, S, Caamano, J, Jorgensen, HF, Carobbio, S, Vidal-Puig, A & McKenzie, ANJ 2019, 'A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue', The Journal of Experimental Medicine, vol. 216, no. 9, pp. 1999-2009. https://doi.org/10.1084/jem.20190689

TY - JOUR

T1 - A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

AU - Rana, Batika M. J.

AU - Jou, Eric

AU - Barlow, Jillian L.

AU - Rodriguez-Rodriguez, Noe

AU - Walker, Jennifer A.

AU - Knox, Claire

AU - Jolin, Helen E.

AU - Hardman, Clare S.

AU - Sivasubramaniam, Meera

AU - Szeto, Aydan

AU - Cohen, E. Suzanne

AU - Scott, Ian C.

AU - Sleeman, Matthew A.

AU - Chidomere, Chiamaka I.

AU - Cruz Migoni, Sara

AU - Caamano, Jorge

AU - Jorgensen, Helle F.

AU - Carobbio, Stefania

AU - Vidal-Puig, Antonio

AU - McKenzie, Andrew N. J.

PY - 2019/9/2

Y1 - 2019/9/2

N2 - Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1-mediated proliferation and activation of LFA-1-expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT.

AB - Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1-mediated proliferation and activation of LFA-1-expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT.

UR - http://www.scopus.com/inward/record.url?scp=85071635520&partnerID=8YFLogxK

U2 - 10.1084/jem.20190689

DO - 10.1084/jem.20190689

M3 - Article

C2 - 31248899

SN - 0022-1007

VL - 216

SP - 1999

EP - 2009

JO - The Journal of Experimental Medicine

JF - The Journal of Experimental Medicine

IS - 9

ER -

A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

Abstract

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this