A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

Batika M J Rana, Eric Jou, Jillian L Barlow, Noe Rodriguez-Rodriguez, Jennifer A Walker, Claire Knox, Helen E Jolin, Clare S Hardman, Meera Sivasubramaniam, Aydan Szeto, E Suzanne Cohen, Ian C Scott, Matthew A Sleeman, Chiamaka I Chidomere, Sara Cruz Migoni, Jorge Caamano, Helle F Jorgensen, Stefania Carobbio, Antonio Vidal-Puig, Andrew N J McKenzie

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)
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Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1-mediated proliferation and activation of LFA-1-expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT.

Original languageEnglish
Pages (from-to)1999-2009
Number of pages11
JournalThe Journal of Experimental Medicine
Issue number9
Early online date27 Jun 2019
Publication statusPublished - 2 Sept 2019

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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