A stable start: cotranslational Nt-acetylation promotes proteome stability across kingdoms

Research output: Contribution to journalArticle

Abstract

Two recent studies show that cotranslational N-terminal protein acetylation (NTA) promotes proteome stability in humans (Mueller et al.) and plants (Linster et al.) by masking nonacetylated N-degrons that would otherwise destabilise proteins. This is in contrast to previous findings linking NTA to degradation, suggesting that this widespread mark has complex and context-specific functions in regulating protein half-lives.
Original languageEnglish
JournalTrends in Cell Biology
Early online date5 Mar 2022
DOIs
Publication statusE-pub ahead of print - 5 Mar 2022

Keywords

  • acetylation
  • N terminus
  • cotranslational modification
  • proteolysis
  • N-degron pathway
  • proteostasis

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