Abstract
Two recent studies show that cotranslational N-terminal protein acetylation (NTA) promotes proteome stability in humans (Mueller et al.) and plants (Linster et al.) by masking nonacetylated N-degrons that would otherwise destabilise proteins. This is in contrast to previous findings linking NTA to degradation, suggesting that this widespread mark has complex and context-specific functions in regulating protein half-lives.
Original language | English |
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Pages (from-to) | 374-376 |
Journal | Trends in Cell Biology |
Volume | 32 |
Issue number | 5 |
Early online date | 5 Mar 2022 |
DOIs | |
Publication status | E-pub ahead of print - 5 Mar 2022 |
Keywords
- N terminus
- N-degron pathway
- acetylation
- cotranslational modification
- proteolysis
- proteostasis