A stable start: cotranslational Nt-acetylation promotes proteome stability across kingdoms

Daniel J. Gibbs; Mark Bailey; Ross D. Etherington

doi:10.1016/j.tcb.2022.02.004

A stable start: cotranslational Nt-acetylation promotes proteome stability across kingdoms

Daniel J. Gibbs, Mark Bailey, Ross D. Etherington

Biosciences

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Abstract

Two recent studies show that cotranslational N-terminal protein acetylation (NTA) promotes proteome stability in humans (Mueller et al.) and plants (Linster et al.) by masking nonacetylated N-degrons that would otherwise destabilise proteins. This is in contrast to previous findings linking NTA to degradation, suggesting that this widespread mark has complex and context-specific functions in regulating protein half-lives.

Original language	English
Pages (from-to)	374-376
Journal	Trends in Cell Biology
Volume	32
Issue number	5
Early online date	5 Mar 2022
DOIs	https://doi.org/10.1016/j.tcb.2022.02.004
Publication status	E-pub ahead of print - 5 Mar 2022

Keywords

N terminus
N-degron pathway
acetylation
cotranslational modification
proteolysis
proteostasis

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10.1016/j.tcb.2022.02.004

GibbsD2022stableAccepted author manuscript, 66 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

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abstract = "Two recent studies show that cotranslational N-terminal protein acetylation (NTA) promotes proteome stability in humans (Mueller et al.) and plants (Linster et al.) by masking nonacetylated N-degrons that would otherwise destabilise proteins. This is in contrast to previous findings linking NTA to degradation, suggesting that this widespread mark has complex and context-specific functions in regulating protein half-lives.",

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A stable start: cotranslational Nt-acetylation promotes proteome stability across kingdoms

Abstract

Keywords

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