A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels

Hoi Kin Wong, Kwok Leung Ong, Raymond Y H Leung, Tai Hing Lam, Graham Neil Thomas, Karen S L Lam, Bernard M Y Cheung

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)


    OBJECTIVE: Elevated plasma adrenomedullin (ADM) levels are associated with cardiovascular diseases. Single nucleotide polymorphisms (SNPs) in the gene encoding ADM (ADM) are associated with plasma ADM levels. The presence of a nuclear factor for interleukin-6 (IL-6) expression binding site in the promoter region of the ADM gene suggests a possible relationship between the expression of the ADM and IL-6. Therefore, we investigated whether plasma ADM levels are related to SNPs in the gene encoding IL-6 (IL6).

    METHODS: Plasma ADM levels were measured in 476 subjects in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2). The subjects were genotyped for three tagging SNPs in the IL6 gene.

    RESULTS: The minor allele frequencies of the IL6 SNPs rs17147230, rs1800796 and rs2069837 were 41·8%, 20·0% and 15·4%, respectively. The tagging SNP, rs17147230, was associated with plasma ADM levels after adjusting for age and sex (β=-0·096, P = 0·034). The association was significant in women (β=-0·115, P = 0·021) but not in men. Among all subjects, plasma ADM levels decreased with an increasing number of minor alleles of rs17147230 in multivariate analysis (P = 0·034). Compared to subjects with the AA genotype, subjects with the TT genotype had plasma ADM levels 12·8% lower (95% CI: 0·6-23·5%, P = 0·041). Haplotype analysis demonstrated a significant association of the haplotype ACA with plasma ADM levels in women (P < 0·05).

    CONCLUSION: Plasma ADM levels are related to the SNP rs17147230 in IL6 gene. The effect of the polymorphism on inflammation and cardiovascular disease remains to be determined.

    Original languageEnglish
    Pages (from-to)504-9
    Number of pages6
    JournalClinical Endocrinology
    Issue number4
    Publication statusPublished - Oct 2013


    • Adrenomedullin
    • Adult
    • Asian Continental Ancestry Group
    • Cardiovascular Diseases
    • Female
    • Gene Frequency
    • Genotype
    • Haplotypes
    • Hong Kong
    • Humans
    • Interleukin-6
    • Male
    • Middle Aged
    • Multivariate Analysis
    • Polymorphism, Single Nucleotide
    • Prevalence
    • Risk Factors
    • Sex Factors


    Dive into the research topics of 'A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels'. Together they form a unique fingerprint.

    Cite this