A review of retroperitoneal liposarcoma genomics

Robert Tyler, Kasun Wanigasooriya, Philippe Taniere, Max Almond, Samuel Ford, Anant Desai, Andrew Beggs

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)
86 Downloads (Pure)

Abstract

Retroperitoneal liposarcomas are rare tumours that carry a poorer prognosis than their extremity counterparts. Within their subtypes - well differentiated (WDL), dedifferentiated (DDL), myxoid (MLS) and pleomorphic (PLS) - they exhibit a diverse genomic landscape. With recent advances in next generation sequencing, the number of studies exploring this have greatly increased. The recent literature has deepened our understanding of the hallmark MDM2/CDK4 amplification in WDL/DDL and addressed concerns about toxicity and resistance when targeting this. The FUS-DDIT3 fusion gene remains the primary focus of interest in MLS with additional potential targets described. Whole genome sequencing has driven identification of novel genes and pathways implicated in WDL/DDL outside of the classic 12q13-15 amplicon. Due to their rarity; anatomical location and histologic subtype are infrequently mentioned when reporting the results of these studies. Reports can include non-adipogenic or extremity tumours, making it difficult to draw specific retroperitoneal conclusions. This narrative review aims to provide a summary of retroperitoneal liposarcoma genomics and the implications for therapeutic targeting.

Original languageEnglish
Article number102013
JournalCancer Treatment Reviews
Volume86
Early online date28 Mar 2020
DOIs
Publication statusPublished - Jun 2020

Keywords

  • liposarcoma
  • retroperitoneal
  • genomics
  • therapeutics
  • review

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