A review of functional and structural neuroimaging studies to investigate the inner speech model of auditory verbal hallucinations in schizophrenia

Research output: Contribution to journalReview articlepeer-review

5 Downloads (Pure)

Abstract

Although the pathophysiology of auditory verbal hallucinations remains uncertain, the inner speech model remains a prominent theory. A systematic review and meta-analyses of both functional and structural neuroimaging studies were performed to investigate the inner speech model. Of the 417 papers retrieved, 26 met the inclusion criteria. Meta-analyses found the left insula to be significantly active during auditory verbal hallucinations and to have a significantly reduced grey matter volume in hallucinators. Dysfunction of the left insula may contribute to the misattribution of inner speech due to its suggested roles in both inner speech production and the salience network. No significant activity was found at Broca’s area or Heschl’s gyrus during auditory verbal hallucinations. Furthermore, no structural abnormalities were found at these sites or in the arcuate fasciculi. Overall, evidence was found to both support and oppose the inner speech model. Further research should particularly include a systematic review of task-based trait studies with a focus on inner speech production and self-referential processing, and analyses of additional language-related white matter tracts.
Original languageEnglish
Article number582
JournalTranslational Psychiatry
Volume11
Issue number1
DOIs
Publication statusPublished - 11 Nov 2021

Keywords

  • auditory verbal hallucinations
  • schizophrenia
  • inner speech
  • self-referential processing
  • functional neuroimaging
  • voxel-based morphometry
  • diffusion tensor imaging
  • activation likelihood estimation
  • insula

Fingerprint

Dive into the research topics of 'A review of functional and structural neuroimaging studies to investigate the inner speech model of auditory verbal hallucinations in schizophrenia'. Together they form a unique fingerprint.

Cite this