A retrospective cohort study of patients treated with anti-tuberculous therapy for presumed ocular tuberculosis

Erika Marie Damato, Sarah Dawson, Xiaoxuan Liu, Chandoshi Mukherjee, John Horsburgh, Alastair K. Denniston, Edward Moran, Martin Dedicoat, Philip Ian Murray

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7 Citations (Scopus)
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Abstract

Background: Uveitis involving the posterior segment is a significant and potentially blinding condition. The diagnosis and treatment of patients with uveitis associated with tuberculosis remains controversial, and commonly, patients are systemically well. Use of the interferon-gamma release assays has added to the controversy, as the significance of a positive test may be uncertain. We aim to report the outcomes of anti-tuberculous treatment in a cohort of patients treated in Birmingham, for presumed “ocular tuberculosis”, based on clinical findings, systemic assessment and specific testing for tuberculosis.


Results: We found that in our cohort of 41 patients treated between 2010 and 2014, the majority achieved disease-free remission, even in cases where anti-tuberculous treatment was delayed.


Conclusions: Despite controversy, this study strongly supports the use of anti-tuberculous therapy in such patients and highlights the need for formal prospective trials and treatment protocols.
Original languageEnglish
JournalJournal of Ophthalmic Inflammation and Infection
Volume7
Issue number23
DOIs
Publication statusPublished - 4 Dec 2017

Keywords

  • uveitis
  • anti-tuberculosis therapy
  • tuberculosis
  • interferon-gamma release assay

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