A reproducibility study of a TDI-based method to calculate indices of arterial stiffness.

Martin Claridge, Gareth Bate, JA Dineley, PR Hoskins, T Marshall, Donald Adam, Andrew Bradbury, AB Wilmink

Research output: Contribution to journalArticle

10 Citations (Scopus)


The aim of the study was to investigate the reproducibility of estimation of Young's modulus E and pressure strain elastic modulus Ep, derived from a tissue Doppler imaging (TDI) wall motion technique. Healthy subjects had their arteries insonated at the same sitting by two different observers and at two different sittings by the same observer. From 32 subjects in the reproducibility study, within-scan coefficient of variation (CV) was 4.5%. Intraobserver between-scan CV for E was 12.7% and for Ep 11.0%. Interobserver CVs were 8.3% and 9.3%, respectively. TDI is a reproducible, valid and highly sensitive direct assessment of arterial wall parameters. It is at least as reproducible as other ultrasound based methods for assessing arterial stiffness and also provides increased information about the arterial distension waveform.
Original languageEnglish
Pages (from-to)215-20
Number of pages6
JournalUltrasound in Medicine & Biology
Issue number2
Publication statusPublished - 1 Feb 2008


  • pressure strain elastic modulus
  • reproducibility
  • Doppler ultrasound
  • distension waveform
  • tissue Doppler imaging
  • common carotid artery
  • arterial stiffness
  • Young's modulus


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