A redox-activated G-quadruplex DNA binder based on a platinum(IV)–salphen complex

S. Bandeira, J. Gonzalez-Garcia, E. Pensa, T. Albrecht, R. Vilar

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


There has been increasing interest in the development of small molecules that can selectively bind to G‐quadruplex DNA structures. The latter have been associated with a number of key biological processes and therefore are proposed to be potential targets for drug development. Herein, we report the first example of a reduction‐activated G‐quadruplex DNA binder. We show that a new octahedral platinum(IV)–salphen complex does not interact with DNA in aqueous media at pH 7.4; however, upon addition of bioreductants such as ascorbic acid or glutathione, the compound is readily reduced to the corresponding square planar platinum(II) complex. In contrast to the parent platinum(IV) complex, the in situ generated platinum(II) complex has good affinity for G‐quadruplex DNA.
Original languageEnglish
Pages (from-to)310-313
Number of pages4
JournalAngewandte Chemie (International Edition)
Issue number1
Early online date17 Nov 2017
Publication statusPublished - 2 Jan 2018


  • antitumor agents
  • DNA structures
  • drug targeting
  • G-quadruplexes
  • platinum


Dive into the research topics of 'A redox-activated G-quadruplex DNA binder based on a platinum(IV)–salphen complex'. Together they form a unique fingerprint.

Cite this