A randomized controlled trial of recombinant interferon-beta 1a in Guillain-Barre syndrome

J Pritchard; IA Grau; ZR Idrissova; BR Lecky; Ian Sutton; AW Swan; HJ Willison; John Winer; RA Hughes

A randomized controlled trial of recombinant interferon-beta 1a in Guillain-Barre syndrome

J Pritchard, IA Grau, ZR Idrissova, BR Lecky, Ian Sutton, AW Swan, HJ Willison, John Winer, RA Hughes

Birmingham Medical School

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52 Citations (Scopus)

Abstract

The authors recruited 19 nonambulant patients with Guillain-Barré syndrome into a pilot, double-blind, randomized, placebo-controlled safety trial of interferon beta 1a (IFN[beta]-1a) (Rebif). Participants received IFN[beta]-1a or placebo subcutaneously three times weekly, 22 microg for the first week and then 44 microg for up to 24 weeks, in addition to IV immunoglobulin (IVIg). IFN[beta] did not have any unexpected interaction with IVIg and there was no significant difference in rate of improvement.

Original language	English
Pages (from-to)	1282-4
Number of pages	3
Journal	Neurology
Volume	61
Issue number	9
Publication status	Published - 1 Jan 2003

Cite this

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title = "A randomized controlled trial of recombinant interferon-beta 1a in Guillain-Barre syndrome",

abstract = "The authors recruited 19 nonambulant patients with Guillain-Barr{\'e} syndrome into a pilot, double-blind, randomized, placebo-controlled safety trial of interferon beta 1a (IFN[beta]-1a) (Rebif). Participants received IFN[beta]-1a or placebo subcutaneously three times weekly, 22 microg for the first week and then 44 microg for up to 24 weeks, in addition to IV immunoglobulin (IVIg). IFN[beta] did not have any unexpected interaction with IVIg and there was no significant difference in rate of improvement.",

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AU - Pritchard, J

AU - Grau, IA

AU - Idrissova, ZR

AU - Lecky, BR

AU - Sutton, Ian

AU - Swan, AW

AU - Willison, HJ

AU - Winer, John

AU - Hughes, RA

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N2 - The authors recruited 19 nonambulant patients with Guillain-Barré syndrome into a pilot, double-blind, randomized, placebo-controlled safety trial of interferon beta 1a (IFN[beta]-1a) (Rebif). Participants received IFN[beta]-1a or placebo subcutaneously three times weekly, 22 microg for the first week and then 44 microg for up to 24 weeks, in addition to IV immunoglobulin (IVIg). IFN[beta] did not have any unexpected interaction with IVIg and there was no significant difference in rate of improvement.

AB - The authors recruited 19 nonambulant patients with Guillain-Barré syndrome into a pilot, double-blind, randomized, placebo-controlled safety trial of interferon beta 1a (IFN[beta]-1a) (Rebif). Participants received IFN[beta]-1a or placebo subcutaneously three times weekly, 22 microg for the first week and then 44 microg for up to 24 weeks, in addition to IV immunoglobulin (IVIg). IFN[beta] did not have any unexpected interaction with IVIg and there was no significant difference in rate of improvement.

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VL - 61

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JO - Neurology

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A randomized controlled trial of recombinant interferon-beta 1a in Guillain-Barre syndrome

Abstract

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