A QSAR study investigating the effect of L-alanine ester variation on the anti-HIV activity of some phosphoramidate derivatives of d4T

M H Knaggs; C McGuigan; Sarah Knaggs; P Heshmati; D Cahard; I H Gilbert; J Balzarini

A QSAR study investigating the effect of L-alanine ester variation on the anti-HIV activity of some phosphoramidate derivatives of d4T

M H Knaggs, C McGuigan, Sarah Knaggs, P Heshmati, D Cahard, I H Gilbert, J Balzarini

Dentistry

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Abstract

A QSAR study, involving the use of calculated physical properties (TSAR), and the use of a neural network approach (TSAR), has been performed concerning the anti-HIV activity and cytotoxic effects of a series of d4T phosphoramidate derivatives with varying L-alanine esters. Models were obtained which allow reliable predictions for the anti-HIV activity, and cytotoxicity, of these derivatives.

Original language	English
Pages (from-to)	2075-8
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	10
Issue number	18
Publication status	Published - 2000

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abstract = "A QSAR study, involving the use of calculated physical properties (TSAR), and the use of a neural network approach (TSAR), has been performed concerning the anti-HIV activity and cytotoxic effects of a series of d4T phosphoramidate derivatives with varying L-alanine esters. Models were obtained which allow reliable predictions for the anti-HIV activity, and cytotoxicity, of these derivatives.",

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AU - Heshmati, P

AU - Cahard, D

AU - Gilbert, I H

AU - Balzarini, J

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AB - A QSAR study, involving the use of calculated physical properties (TSAR), and the use of a neural network approach (TSAR), has been performed concerning the anti-HIV activity and cytotoxic effects of a series of d4T phosphoramidate derivatives with varying L-alanine esters. Models were obtained which allow reliable predictions for the anti-HIV activity, and cytotoxicity, of these derivatives.

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ER -

A QSAR study investigating the effect of L-alanine ester variation on the anti-HIV activity of some phosphoramidate derivatives of d4T

Abstract

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