A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

Y. Nakano; I. Guerrero; A. Hidalgo; A. Taylor; J. R. S. Whittle; P. W. Ingham

doi:10.1038/341508a0

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

Y. Nakano
, I. Guerrero
, A. Hidalgo
, A. Taylor
, J. R. S. Whittle
, P. W. Ingham

Biosciences

Research output: Contribution to journal › Article › peer-review

275 Citations (Scopus)

Abstract

The patterning of cells in insect segments requires the exchange of information between cells, which in Drosophila depends on the activity of members of the segment-polarity class of genes. Here we report the molecular characterization of one such gene, patched. We find that patched encodes a large protein with several possible membrane-spanning domains and is expressed in a complex pattern during embryogenesis.

Original language	English
Pages (from-to)	508-513
Number of pages	6
Journal	Nature
Volume	341
Issue number	6242
DOIs	https://doi.org/10.1038/341508a0
Publication status	Published - 12 Oct 1989

Keywords

Alleles
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
DNA
Drosophila
Embryo, Nonmammalian
Genes
Membrane Proteins
Molecular Sequence Data
Protein Conformation
Restriction Mapping
Journal Article
Research Support, Non-U.S. Gov't

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10.1038/341508a0

Cite this

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title = "A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched",

abstract = "The patterning of cells in insect segments requires the exchange of information between cells, which in Drosophila depends on the activity of members of the segment-polarity class of genes. Here we report the molecular characterization of one such gene, patched. We find that patched encodes a large protein with several possible membrane-spanning domains and is expressed in a complex pattern during embryogenesis.",

keywords = "Alleles, Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, DNA, Drosophila, Embryo, Nonmammalian, Genes, Membrane Proteins, Molecular Sequence Data, Protein Conformation, Restriction Mapping, Journal Article, Research Support, Non-U.S. Gov't",

author = "Y. Nakano and I. Guerrero and A. Hidalgo and A. Taylor and Whittle, \{J. R. S.\} and Ingham, \{P. W.\}",

year = "1989",

month = oct,

day = "12",

doi = "10.1038/341508a0",

language = "English",

volume = "341",

pages = "508--513",

journal = "Nature",

issn = "0028-0836",

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TY - JOUR

T1 - A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

AU - Nakano, Y.

AU - Guerrero, I.

AU - Hidalgo, A.

AU - Taylor, A.

AU - Whittle, J. R. S.

AU - Ingham, P. W.

PY - 1989/10/12

Y1 - 1989/10/12

N2 - The patterning of cells in insect segments requires the exchange of information between cells, which in Drosophila depends on the activity of members of the segment-polarity class of genes. Here we report the molecular characterization of one such gene, patched. We find that patched encodes a large protein with several possible membrane-spanning domains and is expressed in a complex pattern during embryogenesis.

AB - The patterning of cells in insect segments requires the exchange of information between cells, which in Drosophila depends on the activity of members of the segment-polarity class of genes. Here we report the molecular characterization of one such gene, patched. We find that patched encodes a large protein with several possible membrane-spanning domains and is expressed in a complex pattern during embryogenesis.

KW - Alleles

KW - Amino Acid Sequence

KW - Animals

KW - Base Sequence

KW - Cloning, Molecular

KW - DNA

KW - Drosophila

KW - Embryo, Nonmammalian

KW - Genes

KW - Membrane Proteins

KW - Molecular Sequence Data

KW - Protein Conformation

KW - Restriction Mapping

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/341508a0

DO - 10.1038/341508a0

M3 - Article

C2 - 2797178

SN - 0028-0836

VL - 341

SP - 508

EP - 513

JO - Nature

JF - Nature

IS - 6242

ER -

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

Abstract

Keywords

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