A protein complex that regulates PtdIns(3,5)P2 levels.

Robert Michell, Stephen Dove

Research output: Contribution to journalComment/debate

19 Citations (Scopus)


Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) is needed for retrograde membrane trafficking from lysosomal and late endosomal compartments and its synthesis is tightly regulated. But how cells regulate PtdIns(3,5)P2 synthesis--for example, in response to hyperosmotic shock--remains unexplained. A paper from the Weisman group gives the most complete picture so far of a multiprotein complex that controls PtdIns(3,5)P2 synthesis and explains how a VAC14 mutation functionally impairs the scaffold protein at the heart of the complex and causes a neurodegenerative condition in mice.
Original languageEnglish
Pages (from-to)86-7
Number of pages2
JournalThe EMBO journal
Issue number2
Publication statusPublished - 21 Jan 2009


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