TY - JOUR
T1 - A Prehistory of Cell Adhesion
AU - Harwood, AJ
AU - Coates, Juliet
PY - 2004/1/1
Y1 - 2004/1/1
N2 - Cell adhesion is a basic property of animal cells, but is also present in many other eukaryotes. Did cell adhesion systems arise independently in different eukaryotic groups, or do they share common origins? Recent results show that cell adhesion proteins related to cadherin, IgG-like CAM and C-type lectin are present both in sponges, the most distant animal branch, and in eukaryote groups outside the metazoan lineage, indicating that these forms of adhesion arose prior to animal evolution. Furthermore, proteins containing features of animal adhesion systems, such as Fas-1 and thrombospondin domains, are distributed throughout the eukaryotes and function in cell adhesion.
AB - Cell adhesion is a basic property of animal cells, but is also present in many other eukaryotes. Did cell adhesion systems arise independently in different eukaryotic groups, or do they share common origins? Recent results show that cell adhesion proteins related to cadherin, IgG-like CAM and C-type lectin are present both in sponges, the most distant animal branch, and in eukaryote groups outside the metazoan lineage, indicating that these forms of adhesion arose prior to animal evolution. Furthermore, proteins containing features of animal adhesion systems, such as Fas-1 and thrombospondin domains, are distributed throughout the eukaryotes and function in cell adhesion.
UR - http://www.scopus.com/inward/record.url?scp=4444355854&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2004.07.011
DO - 10.1016/j.ceb.2004.07.011
M3 - Review article
C2 - 15363795
VL - 16
SP - 470
EP - 476
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -