A pooled analysis of thyroid cancer incidence following radiotherapy for childhood cancer

Lene H S Veiga; Jay H Lubin; Harald Anderson; Florent de Vathaire; Margaret Tucker; Parveen Bhatti; Arthur Schneider; Robert Johansson; Peter Inskip; Ruth Kleinerman; Roy Shore; Linda Pottern; Erik Holmberg; Michael M Hawkins; M Jacob Adams; Siegal Sadetzki; Marie Lundell; Ritsu Sakata; Lena Damber; Gila Neta; Elaine Ron

A pooled analysis of thyroid cancer incidence following radiotherapy for childhood cancer

Lene H S Veiga
, Jay H Lubin
, Harald Anderson
, Florent de Vathaire
, Margaret Tucker
, Parveen Bhatti
, Arthur Schneider
, Robert Johansson
, Peter Inskip
, Ruth Kleinerman
, Roy Shore
, Linda Pottern
, Erik Holmberg
, Michael M Hawkins
, M Jacob Adams
, Siegal Sadetzki
, Marie Lundell
, Ritsu Sakata
, Lena Damber
, Gila Neta

Elaine Ron

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

Childhood cancer five-year survival now exceeds 70-80%. Childhood exposure to radiation is a known thyroid carcinogen; however, data are limited for the evaluation of radiation dose-response at high doses, modifiers of the dose-response relationship and joint effects of radiotherapy and chemotherapy. To address these issues, we pooled two cohort and two nested case-control studies of childhood cancer survivors including 16,757 patients, with 187 developing primary thyroid cancer. Relative risks (RR) with 95% confidence intervals (CI) for thyroid cancer by treatment with alkylating agents, anthracyclines or bleomycin were 3.25 (0.9-14.9), 4.5 (1.4-17.8) and 3.2 (0.8-10.4), respectively, in patients without radiotherapy, and declined with greater radiation dose (RR trends, P = 0.02, 0.12 and 0.01, respectively). Radiation dose-related RRs increased approximately linearly for 50 Gy. The fitted RR at 10 Gy was 13.7 (95% CI: 8.0-24.0). Dose-related excess RRs increased with decreasing age at exposure (P

Original language	English
Pages (from-to)	365-76
Journal	Radiation Research
Volume	178
Issue number	4
Publication status	Published - Oct 2012

Keywords

Adolescent
Adult
Case-Control Studies
Child
Child, Preschool
Dose-Response Relationship, Radiation
Female
Humans
Incidence
Infant
Male
Neoplasms
Neoplasms, Radiation-Induced
Neoplasms, Second Primary
Radiotherapy
Thyroid Neoplasms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Veiga, L. H. S., Lubin, J. H., Anderson, H., de Vathaire, F., Tucker, M., Bhatti, P., Schneider, A., Johansson, R., Inskip, P., Kleinerman, R., Shore, R., Pottern, L., Holmberg, E., Hawkins, M. M., Adams, M. J., Sadetzki, S., Lundell, M., Sakata, R., Damber, L., ... Ron, E. (2012). A pooled analysis of thyroid cancer incidence following radiotherapy for childhood cancer. Radiation Research, 178(4), 365-76.

@article{f052c7bd29a24641a893753efe5670e4,

title = "A pooled analysis of thyroid cancer incidence following radiotherapy for childhood cancer",

abstract = "Childhood cancer five-year survival now exceeds 70-80\%. Childhood exposure to radiation is a known thyroid carcinogen; however, data are limited for the evaluation of radiation dose-response at high doses, modifiers of the dose-response relationship and joint effects of radiotherapy and chemotherapy. To address these issues, we pooled two cohort and two nested case-control studies of childhood cancer survivors including 16,757 patients, with 187 developing primary thyroid cancer. Relative risks (RR) with 95\% confidence intervals (CI) for thyroid cancer by treatment with alkylating agents, anthracyclines or bleomycin were 3.25 (0.9-14.9), 4.5 (1.4-17.8) and 3.2 (0.8-10.4), respectively, in patients without radiotherapy, and declined with greater radiation dose (RR trends, P = 0.02, 0.12 and 0.01, respectively). Radiation dose-related RRs increased approximately linearly for 50 Gy. The fitted RR at 10 Gy was 13.7 (95\% CI: 8.0-24.0). Dose-related excess RRs increased with decreasing age at exposure (P ",

keywords = "Adolescent, Adult, Case-Control Studies, Child, Child, Preschool, Dose-Response Relationship, Radiation, Female, Humans, Incidence, Infant, Male, Neoplasms, Neoplasms, Radiation-Induced, Neoplasms, Second Primary, Radiotherapy, Thyroid Neoplasms",

author = "Veiga, \{Lene H S\} and Lubin, \{Jay H\} and Harald Anderson and \{de Vathaire\}, Florent and Margaret Tucker and Parveen Bhatti and Arthur Schneider and Robert Johansson and Peter Inskip and Ruth Kleinerman and Roy Shore and Linda Pottern and Erik Holmberg and Hawkins, \{Michael M\} and Adams, \{M Jacob\} and Siegal Sadetzki and Marie Lundell and Ritsu Sakata and Lena Damber and Gila Neta and Elaine Ron",

year = "2012",

month = oct,

language = "English",

volume = "178",

pages = "365--76",

journal = "Radiation Research",

issn = "0033-7587",

publisher = "Radiation Research Society",

number = "4",

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Veiga, LHS, Lubin, JH, Anderson, H, de Vathaire, F, Tucker, M, Bhatti, P, Schneider, A, Johansson, R, Inskip, P, Kleinerman, R, Shore, R, Pottern, L, Holmberg, E, Hawkins, MM, Adams, MJ, Sadetzki, S, Lundell, M, Sakata, R, Damber, L, Neta, G & Ron, E 2012, 'A pooled analysis of thyroid cancer incidence following radiotherapy for childhood cancer', Radiation Research, vol. 178, no. 4, pp. 365-76.

TY - JOUR

T1 - A pooled analysis of thyroid cancer incidence following radiotherapy for childhood cancer

AU - Veiga, Lene H S

AU - Lubin, Jay H

AU - Anderson, Harald

AU - de Vathaire, Florent

AU - Tucker, Margaret

AU - Bhatti, Parveen

AU - Schneider, Arthur

AU - Johansson, Robert

AU - Inskip, Peter

AU - Kleinerman, Ruth

AU - Shore, Roy

AU - Pottern, Linda

AU - Holmberg, Erik

AU - Hawkins, Michael M

AU - Adams, M Jacob

AU - Sadetzki, Siegal

AU - Lundell, Marie

AU - Sakata, Ritsu

AU - Damber, Lena

AU - Neta, Gila

AU - Ron, Elaine

PY - 2012/10

Y1 - 2012/10

N2 - Childhood cancer five-year survival now exceeds 70-80%. Childhood exposure to radiation is a known thyroid carcinogen; however, data are limited for the evaluation of radiation dose-response at high doses, modifiers of the dose-response relationship and joint effects of radiotherapy and chemotherapy. To address these issues, we pooled two cohort and two nested case-control studies of childhood cancer survivors including 16,757 patients, with 187 developing primary thyroid cancer. Relative risks (RR) with 95% confidence intervals (CI) for thyroid cancer by treatment with alkylating agents, anthracyclines or bleomycin were 3.25 (0.9-14.9), 4.5 (1.4-17.8) and 3.2 (0.8-10.4), respectively, in patients without radiotherapy, and declined with greater radiation dose (RR trends, P = 0.02, 0.12 and 0.01, respectively). Radiation dose-related RRs increased approximately linearly for 50 Gy. The fitted RR at 10 Gy was 13.7 (95% CI: 8.0-24.0). Dose-related excess RRs increased with decreasing age at exposure (P

AB - Childhood cancer five-year survival now exceeds 70-80%. Childhood exposure to radiation is a known thyroid carcinogen; however, data are limited for the evaluation of radiation dose-response at high doses, modifiers of the dose-response relationship and joint effects of radiotherapy and chemotherapy. To address these issues, we pooled two cohort and two nested case-control studies of childhood cancer survivors including 16,757 patients, with 187 developing primary thyroid cancer. Relative risks (RR) with 95% confidence intervals (CI) for thyroid cancer by treatment with alkylating agents, anthracyclines or bleomycin were 3.25 (0.9-14.9), 4.5 (1.4-17.8) and 3.2 (0.8-10.4), respectively, in patients without radiotherapy, and declined with greater radiation dose (RR trends, P = 0.02, 0.12 and 0.01, respectively). Radiation dose-related RRs increased approximately linearly for 50 Gy. The fitted RR at 10 Gy was 13.7 (95% CI: 8.0-24.0). Dose-related excess RRs increased with decreasing age at exposure (P

KW - Adolescent

KW - Adult

KW - Case-Control Studies

KW - Child

KW - Child, Preschool

KW - Dose-Response Relationship, Radiation

KW - Female

KW - Humans

KW - Incidence

KW - Infant

KW - Male

KW - Neoplasms

KW - Neoplasms, Radiation-Induced

KW - Neoplasms, Second Primary

KW - Radiotherapy

KW - Thyroid Neoplasms

M3 - Article

C2 - 22857014

SN - 0033-7587

VL - 178

SP - 365

EP - 376

JO - Radiation Research

JF - Radiation Research

IS - 4

ER -

A pooled analysis of thyroid cancer incidence following radiotherapy for childhood cancer

Abstract

Keywords

UN SDGs

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