A novel protecting group methodology for syntheses using nitroxides

Benjamin A. Chalmers, Jason C. Morris, Kathryn E. Fairfull-Smith, Richard S. Grainger, Steven E. Bottle*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


The methoxyamine group represents an ideal protecting group for the nitroxide moiety. It can be easily and selectively introduced in high yield (typically >90%) to a range of functionalised nitroxides using FeSO 4·7H2O and H2O2 in DMSO. Its removal is readily achieved under mild conditions in high yield (70-90%) using mCPBA in a Cope-type elimination process.

Original languageEnglish
Pages (from-to)10382-10384
Number of pages3
JournalChemical Communications
Issue number88
Publication statusPublished - 14 Nov 2013

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


Dive into the research topics of 'A novel protecting group methodology for syntheses using nitroxides'. Together they form a unique fingerprint.

Cite this