A novel exchange method to access sulfated molecules

Jaber A Alshehri, Anna Mary Benedetti, Alan M Jones

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
162 Downloads (Pure)


Organosulfates and sulfamates are important classes of bioactive molecules but due to their polar nature, they are both difficult to prepare and purify. We report an operationally simple, double ion-exchange method to access organosulfates and sulfamates. Inspired by the novel sulfating reagent, TriButylSulfoAmmonium Betaine (TBSAB), we developed a 3-step procedure using tributylamine as the novel solubilising partner coupled to commercially available sulfating agents. Hence, in response to an increasing demand for complementary methods to synthesise organosulfates, we developed an alternative sulfation route based on an inexpensive, molecularly efficient and solubilising cation exchanging method using off-the-shelf reagents. The disclosed method is amenable to a range of differentially substituted benzyl alcohols, benzylamines and aniline and can also be performed at low temperature for sensitive substrates in good to excellent isolated yield.

Original languageEnglish
Article number16559
JournalScientific Reports
Issue number1
Publication statusPublished - 6 Oct 2020


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