A narrative review of current evidence supporting the implementation of electronic patient-reported outcome measures in the management of chronic diseases

Olalekan Lee Aiyegbusi, Devika Nair, John Devin Peipert, Kara Schick-Makaroff, Istvan Mucsi

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An application of telemedicine of growing interest and relevance is the use of personal computers and mobile devices to collect patient-reported outcomes (PROs). PROs are self-reports of patients’ health status without interpretation by anyone else. The tools developed to assess PROs are known as patient-reported outcomes measures (PROMs). The technological innovations that have led to an increased ownership of electronic devices have also facilitated the development of electronic PROMs (ePROMs). ePROMs are a conduit for telemedicine in the care of patients with chronic diseases. Various studies have demonstrated that the use of ePROMs in routine clinical practice is both acceptable and feasible with patients increasingly expressing a preference for an electronic mode of administration. There is increasing evidence that the use of electronic patient-reported outcome (ePROMs) could have significant impacts on outcomes valued by patients, healthcare providers and researchers. Whilst the development and implementation of these systems may be initially costly and resource-intensive, patient preferences and existing evidence to support their implementation suggests the need for continued research prioritisation in this area. This narrative review summarises and discusses evidence of the impact of ePROMs on clinical parameters and outcomes relevant to chronic diseases. We also explore recently published literature regarding issues that may influence the robust implementation of ePROMs for routine clinical practice.
Original languageEnglish
Number of pages22
JournalTherapeutic advances in chronic disease
Publication statusPublished - 24 May 2021

Bibliographical note

Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: OLA is supported by the National Institute of Health Research (NIHR) Birmingham Biomedical Research Centre (BRC), NIHR Applied Research Centre (ARC), West Midlands at the University of Birmingham and University Hospitals Birmingham NHS Foundation, Innovate UK (part of UK Research and Innovation), Gilead Sciences Ltd, and Janssen Pharmaceuticals, Inc. OLA declares personal fees from Gilead Sciences Ltd, GlaxoSmithKline (GSK) and Merck outside the submitted work. DN receives funding from an Agency for Health Research and Quality/Patient-Centred Outcomes Research Institute Learning Health Systems Scholar K12 award (K12HS026395). IM is funded by the Canadian Institutes of Health Research and the Kidney Foundation of Canada.

Publisher Copyright:
© The Author(s), 2021.


  • Chronic diseases
  • Digital health
  • Electronic patient-reported outcomes
  • Outcome assessment
  • PROs
  • Patient-reported outcomes
  • Quality of life
  • Symptom monitoring
  • ePROM systems
  • ePROs

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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