A Genome-Wide Linkage and Association Scan Reveals Novel Loci for Hypertension and Blood Pressure Traits

Y Guo; B Tomlinson; T Chu; YJ Fang; H Gui; CS Tang; BH Yip; SS Cherny; YM Hur; PC Sham; TH Lam; Neil Thomas

doi:10.1371/journal.pone.0031489

A Genome-Wide Linkage and Association Scan Reveals Novel Loci for Hypertension and Blood Pressure Traits

Y Guo, B Tomlinson, T Chu, YJ Fang, H Gui, CS Tang, BH Yip, SS Cherny, YM Hur, PC Sham, TH Lam, Neil Thomas

Physics and Astronomy

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20 Citations (Scopus)

Abstract

Hypertension is caused by the interaction of environmental and genetic factors. The condition which is very common, with about 18% of the adult Hong Kong Chinese population and over 50% of older individuals affected, is responsible for considerable morbidity and mortality. To identify genes influencing hypertension and blood pressure, we conducted a combined linkage and association study using over 500,000 single nucleotide polymorphisms (SNPs) genotyped in 328 individuals comprising 111 hypertensive probands and their siblings. Using a family-based association test, we found an association with SNPs on chromosome 5q31.1 (rs6596140; P

Original language	English
Pages (from-to)	e31489
Journal	PLoS ONE
Volume	7
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0031489
Publication status	Published - 1 Feb 2012

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AU - Tomlinson, B

AU - Chu, T

AU - Fang, YJ

AU - Gui, H

AU - Tang, CS

AU - Yip, BH

AU - Cherny, SS

AU - Hur, YM

AU - Sham, PC

AU - Lam, TH

AU - Thomas, Neil

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AB - Hypertension is caused by the interaction of environmental and genetic factors. The condition which is very common, with about 18% of the adult Hong Kong Chinese population and over 50% of older individuals affected, is responsible for considerable morbidity and mortality. To identify genes influencing hypertension and blood pressure, we conducted a combined linkage and association study using over 500,000 single nucleotide polymorphisms (SNPs) genotyped in 328 individuals comprising 111 hypertensive probands and their siblings. Using a family-based association test, we found an association with SNPs on chromosome 5q31.1 (rs6596140; P

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A Genome-Wide Linkage and Association Scan Reveals Novel Loci for Hypertension and Blood Pressure Traits

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