A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

Colorectal Tumour Gene Identification (CORGI) Consortium

doi:10.1038/ng.2007.18

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

Colorectal Tumour Gene Identification (CORGI) Consortium

Research output: Contribution to journal › Article › peer-review

418 Citations (Scopus)

Abstract

To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor ( 627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets ( 7,473 cases, 5,984 controls) and identified three SNPs in SMAD7 ( involved in TGF-beta and Wnt signaling) associated with CRC. Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant ( P-trend 1.0 x 10(-12)).

Original language	English
Pages (from-to)	1315-1317
Number of pages	3
Journal	Nature Genetics
Volume	39
Issue number	11
DOIs	https://doi.org/10.1038/ng.2007.18
Publication status	Published - 1 Nov 2007

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title = "A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk",

abstract = "To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor ( 627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets ( 7,473 cases, 5,984 controls) and identified three SNPs in SMAD7 ( involved in TGF-beta and Wnt signaling) associated with CRC. Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant ( P-trend 1.0 x 10(-12)).",

author = "Peter Broderick and Lynn Martin and Richard Gray and Jean-Baptiste Cazier and {Colorectal Tumour Gene Identification (CORGI) Consortium}",

year = "2007",

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AU - Broderick, Peter

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AU - Gray, Richard

AU - Cazier, Jean-Baptiste

AU - Colorectal Tumour Gene Identification (CORGI) Consortium

PY - 2007/11/1

Y1 - 2007/11/1

N2 - To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor ( 627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets ( 7,473 cases, 5,984 controls) and identified three SNPs in SMAD7 ( involved in TGF-beta and Wnt signaling) associated with CRC. Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant ( P-trend 1.0 x 10(-12)).

AB - To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor ( 627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets ( 7,473 cases, 5,984 controls) and identified three SNPs in SMAD7 ( involved in TGF-beta and Wnt signaling) associated with CRC. Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant ( P-trend 1.0 x 10(-12)).

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DO - 10.1038/ng.2007.18

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JO - Nature Genetics

JF - Nature Genetics

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ER -

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

Abstract

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