A farnesoid X receptor polymorphism predisposes to spontaneous bacterial peritonitis

Philipp Lutz; Cordula Berger; Bettina Langhans; Frank Grünhage; Beate Appenrodt; Jacob Nattermann; Frank Lammert; Achim Hoerauf; Tilman Sauerbruch; Christian P Strassburg; Ulrich Spengler; Hans Dieter Nischalke

doi:10.1016/j.dld.2014.07.008

A farnesoid X receptor polymorphism predisposes to spontaneous bacterial peritonitis

Philipp Lutz
, Cordula Berger
, Bettina Langhans
, Frank Grünhage
, Beate Appenrodt
, Jacob Nattermann
, Frank Lammert
, Achim Hoerauf
, Tilman Sauerbruch
, Christian P Strassburg
, Ulrich Spengler
, Hans Dieter Nischalke

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

BACKGROUND: In mice, the farnesoid X receptor is involved in bacterial translocation, which can result in spontaneous bacterial peritonitis in patients with cirrhosis. We investigated if polymorphisms in the farnesoid X receptor gene influence the risk for spontaneous bacterial peritonitis.

METHODS: Laboratory and clinical data of 293 cirrhotic patients with ascites and 226 healthy controls were prospectively collected. The rs56163822, rs11110390 and rs12313471 polymorphisms of the farnesoid X receptor were determined.

RESULTS: 115 (39%) patients had spontaneous bacterial peritonitis. Distribution of all farnesoid X receptor genotypes matched the Hardy-Weinberg equilibrium. Patients with spontaneous bacterial peritonitis had a higher frequency of the rs56163822 GT genotype (7.0%) than patients without (1.7%, OR=4.4, p=0.02). This genotype was confirmed as predictor of spontaneous bacterial peritonitis by binary logistic regression analysis (OR=6.8, p=0.018).

CONCLUSION: The farnesoid X receptor rs56163822 GT genotype increases the risk for spontaneous bacterial peritonitis in cirrhotic patients with ascites.

Original language	English
Pages (from-to)	1047-1050
Number of pages	4
Journal	Digestive and Liver Disease
Volume	46
Issue number	11
Early online date	30 Jul 2014
DOIs	https://doi.org/10.1016/j.dld.2014.07.008
Publication status	Published - Nov 2014

Keywords

Adult
Aged
Aged, 80 and over
Ascites
Bacterial Infections
Case-Control Studies
Confidence Intervals
Female
Genetic Predisposition to Disease
Genotype
Humans
Incidence
Liver Cirrhosis
Logistic Models
Male
Middle Aged
Odds Ratio
Peritonitis
Polymorphism, Genetic
Receptors, Cytoplasmic and Nuclear
Reference Values
Risk Assessment
Statistics, Nonparametric
Young Adult
Farnesoid X receptor
Spontaneous bacterial peritonitis

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https://doi.org/10.1016/j.dld.2014.07.008Licence: None: All rights reserved

Cite this

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title = "A farnesoid X receptor polymorphism predisposes to spontaneous bacterial peritonitis",

abstract = "BACKGROUND: In mice, the farnesoid X receptor is involved in bacterial translocation, which can result in spontaneous bacterial peritonitis in patients with cirrhosis. We investigated if polymorphisms in the farnesoid X receptor gene influence the risk for spontaneous bacterial peritonitis.METHODS: Laboratory and clinical data of 293 cirrhotic patients with ascites and 226 healthy controls were prospectively collected. The rs56163822, rs11110390 and rs12313471 polymorphisms of the farnesoid X receptor were determined.RESULTS: 115 (39\%) patients had spontaneous bacterial peritonitis. Distribution of all farnesoid X receptor genotypes matched the Hardy-Weinberg equilibrium. Patients with spontaneous bacterial peritonitis had a higher frequency of the rs56163822 GT genotype (7.0\%) than patients without (1.7\%, OR=4.4, p=0.02). This genotype was confirmed as predictor of spontaneous bacterial peritonitis by binary logistic regression analysis (OR=6.8, p=0.018).CONCLUSION: The farnesoid X receptor rs56163822 GT genotype increases the risk for spontaneous bacterial peritonitis in cirrhotic patients with ascites.",

keywords = "Adult, Aged, Aged, 80 and over, Ascites, Bacterial Infections, Case-Control Studies, Confidence Intervals, Female, Genetic Predisposition to Disease, Genotype, Humans, Incidence, Liver Cirrhosis, Logistic Models, Male, Middle Aged, Odds Ratio, Peritonitis, Polymorphism, Genetic, Receptors, Cytoplasmic and Nuclear, Reference Values, Risk Assessment, Statistics, Nonparametric, Young Adult, Farnesoid X receptor, Spontaneous bacterial peritonitis",

author = "Philipp Lutz and Cordula Berger and Bettina Langhans and Frank Gr{\"u}nhage and Beate Appenrodt and Jacob Nattermann and Frank Lammert and Achim Hoerauf and Tilman Sauerbruch and Strassburg, \{Christian P\} and Ulrich Spengler and Nischalke, \{Hans Dieter\}",

year = "2014",

month = nov,

doi = "10.1016/j.dld.2014.07.008",

language = "English",

volume = "46",

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journal = "Digestive and Liver Disease",

issn = "1590-8658",

publisher = "Elsevier",

number = "11",

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TY - JOUR

T1 - A farnesoid X receptor polymorphism predisposes to spontaneous bacterial peritonitis

AU - Lutz, Philipp

AU - Berger, Cordula

AU - Langhans, Bettina

AU - Grünhage, Frank

AU - Appenrodt, Beate

AU - Nattermann, Jacob

AU - Lammert, Frank

AU - Hoerauf, Achim

AU - Sauerbruch, Tilman

AU - Strassburg, Christian P

AU - Spengler, Ulrich

AU - Nischalke, Hans Dieter

PY - 2014/11

Y1 - 2014/11

N2 - BACKGROUND: In mice, the farnesoid X receptor is involved in bacterial translocation, which can result in spontaneous bacterial peritonitis in patients with cirrhosis. We investigated if polymorphisms in the farnesoid X receptor gene influence the risk for spontaneous bacterial peritonitis.METHODS: Laboratory and clinical data of 293 cirrhotic patients with ascites and 226 healthy controls were prospectively collected. The rs56163822, rs11110390 and rs12313471 polymorphisms of the farnesoid X receptor were determined.RESULTS: 115 (39%) patients had spontaneous bacterial peritonitis. Distribution of all farnesoid X receptor genotypes matched the Hardy-Weinberg equilibrium. Patients with spontaneous bacterial peritonitis had a higher frequency of the rs56163822 GT genotype (7.0%) than patients without (1.7%, OR=4.4, p=0.02). This genotype was confirmed as predictor of spontaneous bacterial peritonitis by binary logistic regression analysis (OR=6.8, p=0.018).CONCLUSION: The farnesoid X receptor rs56163822 GT genotype increases the risk for spontaneous bacterial peritonitis in cirrhotic patients with ascites.

AB - BACKGROUND: In mice, the farnesoid X receptor is involved in bacterial translocation, which can result in spontaneous bacterial peritonitis in patients with cirrhosis. We investigated if polymorphisms in the farnesoid X receptor gene influence the risk for spontaneous bacterial peritonitis.METHODS: Laboratory and clinical data of 293 cirrhotic patients with ascites and 226 healthy controls were prospectively collected. The rs56163822, rs11110390 and rs12313471 polymorphisms of the farnesoid X receptor were determined.RESULTS: 115 (39%) patients had spontaneous bacterial peritonitis. Distribution of all farnesoid X receptor genotypes matched the Hardy-Weinberg equilibrium. Patients with spontaneous bacterial peritonitis had a higher frequency of the rs56163822 GT genotype (7.0%) than patients without (1.7%, OR=4.4, p=0.02). This genotype was confirmed as predictor of spontaneous bacterial peritonitis by binary logistic regression analysis (OR=6.8, p=0.018).CONCLUSION: The farnesoid X receptor rs56163822 GT genotype increases the risk for spontaneous bacterial peritonitis in cirrhotic patients with ascites.

KW - Adult

KW - Aged

KW - Aged, 80 and over

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KW - Bacterial Infections

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KW - Confidence Intervals

KW - Female

KW - Genetic Predisposition to Disease

KW - Genotype

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KW - Incidence

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KW - Logistic Models

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KW - Middle Aged

KW - Odds Ratio

KW - Peritonitis

KW - Polymorphism, Genetic

KW - Receptors, Cytoplasmic and Nuclear

KW - Reference Values

KW - Risk Assessment

KW - Statistics, Nonparametric

KW - Young Adult

KW - Farnesoid X receptor

KW - Spontaneous bacterial peritonitis

U2 - 10.1016/j.dld.2014.07.008

DO - 10.1016/j.dld.2014.07.008

M3 - Article

C2 - 25086996

SN - 1590-8658

VL - 46

SP - 1047

EP - 1050

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

IS - 11

ER -

A farnesoid X receptor polymorphism predisposes to spontaneous bacterial peritonitis

Abstract

Keywords

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