Abstract
BACKGROUND: In mice, the farnesoid X receptor is involved in bacterial translocation, which can result in spontaneous bacterial peritonitis in patients with cirrhosis. We investigated if polymorphisms in the farnesoid X receptor gene influence the risk for spontaneous bacterial peritonitis.
METHODS: Laboratory and clinical data of 293 cirrhotic patients with ascites and 226 healthy controls were prospectively collected. The rs56163822, rs11110390 and rs12313471 polymorphisms of the farnesoid X receptor were determined.
RESULTS: 115 (39%) patients had spontaneous bacterial peritonitis. Distribution of all farnesoid X receptor genotypes matched the Hardy-Weinberg equilibrium. Patients with spontaneous bacterial peritonitis had a higher frequency of the rs56163822 GT genotype (7.0%) than patients without (1.7%, OR=4.4, p=0.02). This genotype was confirmed as predictor of spontaneous bacterial peritonitis by binary logistic regression analysis (OR=6.8, p=0.018).
CONCLUSION: The farnesoid X receptor rs56163822 GT genotype increases the risk for spontaneous bacterial peritonitis in cirrhotic patients with ascites.
Original language | English |
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Pages (from-to) | 1047-1050 |
Number of pages | 4 |
Journal | Digestive and Liver Disease |
Volume | 46 |
Issue number | 11 |
Early online date | 30 Jul 2014 |
DOIs | |
Publication status | Published - Nov 2014 |
Keywords
- Adult
- Aged
- Aged, 80 and over
- Ascites
- Bacterial Infections
- Case-Control Studies
- Confidence Intervals
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Incidence
- Liver Cirrhosis
- Logistic Models
- Male
- Middle Aged
- Odds Ratio
- Peritonitis
- Polymorphism, Genetic
- Receptors, Cytoplasmic and Nuclear
- Reference Values
- Risk Assessment
- Statistics, Nonparametric
- Young Adult
- Farnesoid X receptor
- Spontaneous bacterial peritonitis