A farnesoid X receptor polymorphism predisposes to spontaneous bacterial peritonitis

Philipp Lutz, Cordula Berger, Bettina Langhans, Frank Grünhage, Beate Appenrodt, Jacob Nattermann, Frank Lammert, Achim Hoerauf, Tilman Sauerbruch, Christian P Strassburg, Ulrich Spengler, Hans Dieter Nischalke

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


BACKGROUND: In mice, the farnesoid X receptor is involved in bacterial translocation, which can result in spontaneous bacterial peritonitis in patients with cirrhosis. We investigated if polymorphisms in the farnesoid X receptor gene influence the risk for spontaneous bacterial peritonitis.

METHODS: Laboratory and clinical data of 293 cirrhotic patients with ascites and 226 healthy controls were prospectively collected. The rs56163822, rs11110390 and rs12313471 polymorphisms of the farnesoid X receptor were determined.

RESULTS: 115 (39%) patients had spontaneous bacterial peritonitis. Distribution of all farnesoid X receptor genotypes matched the Hardy-Weinberg equilibrium. Patients with spontaneous bacterial peritonitis had a higher frequency of the rs56163822 GT genotype (7.0%) than patients without (1.7%, OR=4.4, p=0.02). This genotype was confirmed as predictor of spontaneous bacterial peritonitis by binary logistic regression analysis (OR=6.8, p=0.018).

CONCLUSION: The farnesoid X receptor rs56163822 GT genotype increases the risk for spontaneous bacterial peritonitis in cirrhotic patients with ascites.

Original languageEnglish
Pages (from-to)1047-1050
Number of pages4
JournalDigestive and Liver Disease
Issue number11
Early online date30 Jul 2014
Publication statusPublished - Nov 2014


  • Adult
  • Aged
  • Aged, 80 and over
  • Ascites
  • Bacterial Infections
  • Case-Control Studies
  • Confidence Intervals
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Incidence
  • Liver Cirrhosis
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Peritonitis
  • Polymorphism, Genetic
  • Receptors, Cytoplasmic and Nuclear
  • Reference Values
  • Risk Assessment
  • Statistics, Nonparametric
  • Young Adult
  • Farnesoid X receptor
  • Spontaneous bacterial peritonitis


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