A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis.

Tiezheng Hou, J Bystrom, Jonathan Sherlock, Omar Qureshi, Sonia Parnell, Graham Anderson, DW Gilroy, Christopher Buckley

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29 Citations (Scopus)
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Abstract

Macrophages are important tissue resident cells that regulate the dynamics of inflammation. However, they are strikingly heterogeneous. During studies looking at podoplanin (gp38) expression on stromal cells in the murine spleen and peritoneal cavity we unexpectedly discovered that podoplanin was expressed on a subset of F4/80(+) macrophages; a subset which we have termed fibroblastic macrophages (FM). These cells function as phagocytes in vitro as measured by bead mediated phagocytosis assays. FM also exist at high frequency in the peritoneal cavity and in zymosan induced peritonitis in vivo. These FM represent a unique subgroup of F4/80(+) macrophages and their presence in the inflamed peritoneum suggests that they play a role in zymosan induced peritonitis.
Original languageEnglish
Pages (from-to)3955-61
Number of pages7
JournalFEBS Letters
Volume584
Issue number18
Early online date2 Aug 2010
DOIs
Publication statusPublished - 24 Sep 2010

Keywords

  • Resolution
  • Spleen
  • Podoplanin
  • Phagocytosis
  • Fibroblastic macrophage
  • Inflammation

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