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Abstract
Macrophages are important tissue resident cells that regulate the dynamics of inflammation. However, they are strikingly heterogeneous. During studies looking at podoplanin (gp38) expression on stromal cells in the murine spleen and peritoneal cavity we unexpectedly discovered that podoplanin was expressed on a subset of F4/80(+) macrophages; a subset which we have termed fibroblastic macrophages (FM). These cells function as phagocytes in vitro as measured by bead mediated phagocytosis assays. FM also exist at high frequency in the peritoneal cavity and in zymosan induced peritonitis in vivo. These FM represent a unique subgroup of F4/80(+) macrophages and their presence in the inflamed peritoneum suggests that they play a role in zymosan induced peritonitis.
Original language | English |
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Pages (from-to) | 3955-61 |
Number of pages | 7 |
Journal | FEBS Letters |
Volume | 584 |
Issue number | 18 |
Early online date | 2 Aug 2010 |
DOIs | |
Publication status | Published - 24 Sept 2010 |
Keywords
- Resolution
- Spleen
- Podoplanin
- Phagocytosis
- Fibroblastic macrophage
- Inflammation
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Dive into the research topics of 'A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis.'. Together they form a unique fingerprint.Projects
- 1 Finished
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Generation of Intrathymic Microenvironments to Establish T-Cell Tolerance
Anderson, G., Jenkinson, E. & Lane, P.
1/10/10 → 30/09/15
Project: Research Councils