A Design for Life: Prokaryotic metal-binding MerR family regulators

Jonathan Hobman, John Wilkie, Nigel Brown

Research output: Contribution to journalReview article

69 Citations (Scopus)

Abstract

The MerR family of metal-binding, metal-responsive proteins is unique in that they activate transcription from unusual promoters and coordinate metals through cysteine (and in the case of ZntR, histidine) residues. They have conserved primary structures yet can effectively discriminate metals in vivo.
Original languageEnglish
Pages (from-to)429-36
Number of pages8
JournalBiometals
Volume18
Issue number4
DOIs
Publication statusPublished - 1 Aug 2005

Keywords

  • PbrR
  • MerR regulators
  • CueR
  • ZntR
  • MerR
  • cysteine coordination

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