Abstract
Additive manufacture (AM) of patient specific implants is rapidly growing, however, customized devices typically exhibit higher infection rates. Herein the possibility to differentially control bacterial and mammalian cell attachment on bespoke AM implants by process optimization is demonstrated. Surface analysis of Powder Bed Fusion (PBF) Ti-6Al-4 V cuboidal coupons printed at different orientations revealed an increase in roughness driven by a greater number of partially melted particles on higher angled surfaces, enticing a transition from hydrophilic to hydrophobic contact angles. These changes resulted in a linear increase of adhered S. epidermidis biomass, while osteoblast coverage was maximum for surfaces manufactured at 20 or 30°. To exploit the relationship between low roughness and enhanced biological response, a computational roughness model considering melt pool radii and partially melted particles was developed. Through two implant case studies we demonstrate the ability to predictably minimize surface finish of AM parts in-situ, providing a novel toolset for AM process control. Overall, a method to simultaneously reduce device infection while enhancing native cell attachment has been established, critical to improve musculoskeletal implant performance.
Original language | English |
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Article number | 101528 |
Journal | Additive Manufacturing |
Volume | 36 |
DOIs | |
Publication status | Published - Dec 2020 |
Keywords
- Biofilm prevention
- Cell proliferation
- Powder Bed Fusion
- Surface modelling
- Ti6Al4V process optimization
ASJC Scopus subject areas
- Biomedical Engineering
- General Materials Science
- Engineering (miscellaneous)
- Industrial and Manufacturing Engineering