A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping

Jake A. J. Bewick; Peter R. T. Munro; Simon R. Arridge; James A. Guggenheim

doi:10.1117/12.2656075

A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping

Jake A. J. Bewick
, Peter R. T. Munro
, Simon R. Arridge
, James A. Guggenheim

Cardiovascular Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Photoacoustic (PA) wavefront shaping (WFS; PAWS) could allow focusing light deep in living tissue, increasing the penetration depth of biomedical optics techniques. PAWS experiments have demonstrated focusing light through rigid scattering media. However, focusing deep in tissue is significantly more challenging. To examine the scale of this challenge, a computational model of the propagation of coherent light in tissue was developed to simulate the focusing of light via PAWS. To demonstrate the model, it was used to simulate focusing in an 800 µm thick tissue-like medium. To show the utility of the model, the focusing was repeated in different conditions illustrative of simplified PAWS experiments involving different spatial resolutions. As expected, a finer spatial resolution led to a brighter focus. By providing a simulation platform for studying PAWS, this work could pave the way to developing systems that can focus light in tissue.

Original language	English
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2023
Editors	Alexander A. Oraevsky, Lihong V. Wang
Publisher	SPIE
Number of pages	5
ISBN (Electronic)	9781510658646
ISBN (Print)	9781510658639
DOIs	https://doi.org/10.1117/12.2656075
Publication status	Published - 9 Mar 2023
Event	SPIE Photonics West 2023 - The Moscone Center, San Francisco, United States Duration: 28 Jan 2023 → 2 Feb 2023

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	12379
ISSN (Print)	1605-7422
ISSN (Electronic)	2410-9045

Conference

Conference	SPIE Photonics West 2023
Country/Territory	United States
City	San Francisco
Period	28/01/23 → 2/02/23

Bibliographical note

Publisher Copyright:
© 2023 SPIE.

Keywords

biological tissue
computational simulation
photoacoustic imaging
scattering
T-matrix
Wavefront shaping

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2656075Licence: None: All rights reserved

https://discovery.ucl.ac.uk/id/eprint/10171476Licence: None: All rights reserved

Wavefront shaping for next-generation biomedical photoacoustic imaging
Guggenheim, J. (Principal Investigator)
The Royal Society
1/01/21 → 30/10/23
Project: Research Councils

Cite this

Bewick, J. A. J., Munro, P. R. T., Arridge, S. R., & Guggenheim, J. A. (2023). A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2023 Article 123790D (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12379). SPIE. https://doi.org/10.1117/12.2656075

Bewick, Jake A. J. ; Munro, Peter R. T. ; Arridge, Simon R. et al. / A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping. Photons Plus Ultrasound: Imaging and Sensing 2023. editor / Alexander A. Oraevsky ; Lihong V. Wang. SPIE, 2023. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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title = "A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping",

abstract = "Photoacoustic (PA) wavefront shaping (WFS; PAWS) could allow focusing light deep in living tissue, increasing the penetration depth of biomedical optics techniques. PAWS experiments have demonstrated focusing light through rigid scattering media. However, focusing deep in tissue is significantly more challenging. To examine the scale of this challenge, a computational model of the propagation of coherent light in tissue was developed to simulate the focusing of light via PAWS. To demonstrate the model, it was used to simulate focusing in an 800 µm thick tissue-like medium. To show the utility of the model, the focusing was repeated in different conditions illustrative of simplified PAWS experiments involving different spatial resolutions. As expected, a finer spatial resolution led to a brighter focus. By providing a simulation platform for studying PAWS, this work could pave the way to developing systems that can focus light in tissue.",

keywords = "biological tissue, computational simulation, photoacoustic imaging, scattering, T-matrix, Wavefront shaping",

author = "Bewick, \{Jake A. J.\} and Munro, \{Peter R. T.\} and Arridge, \{Simon R.\} and Guggenheim, \{James A.\}",

note = "Publisher Copyright: {\textcopyright} 2023 SPIE.; SPIE Photonics West 2023 ; Conference date: 28-01-2023 Through 02-02-2023",

year = "2023",

month = mar,

day = "9",

doi = "10.1117/12.2656075",

language = "English",

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series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

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Bewick, JAJ, Munro, PRT, Arridge, SR & Guggenheim, JA 2023, A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2023., 123790D, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12379, SPIE, SPIE Photonics West 2023, San Francisco, California, United States, 28/01/23. https://doi.org/10.1117/12.2656075

A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping. / Bewick, Jake A. J.; Munro, Peter R. T.; Arridge, Simon R. et al.
Photons Plus Ultrasound: Imaging and Sensing 2023. ed. / Alexander A. Oraevsky; Lihong V. Wang. SPIE, 2023. 123790D (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12379).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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T1 - A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping

AU - Bewick, Jake A. J.

AU - Munro, Peter R. T.

AU - Arridge, Simon R.

AU - Guggenheim, James A.

PY - 2023/3/9

Y1 - 2023/3/9

N2 - Photoacoustic (PA) wavefront shaping (WFS; PAWS) could allow focusing light deep in living tissue, increasing the penetration depth of biomedical optics techniques. PAWS experiments have demonstrated focusing light through rigid scattering media. However, focusing deep in tissue is significantly more challenging. To examine the scale of this challenge, a computational model of the propagation of coherent light in tissue was developed to simulate the focusing of light via PAWS. To demonstrate the model, it was used to simulate focusing in an 800 µm thick tissue-like medium. To show the utility of the model, the focusing was repeated in different conditions illustrative of simplified PAWS experiments involving different spatial resolutions. As expected, a finer spatial resolution led to a brighter focus. By providing a simulation platform for studying PAWS, this work could pave the way to developing systems that can focus light in tissue.

AB - Photoacoustic (PA) wavefront shaping (WFS; PAWS) could allow focusing light deep in living tissue, increasing the penetration depth of biomedical optics techniques. PAWS experiments have demonstrated focusing light through rigid scattering media. However, focusing deep in tissue is significantly more challenging. To examine the scale of this challenge, a computational model of the propagation of coherent light in tissue was developed to simulate the focusing of light via PAWS. To demonstrate the model, it was used to simulate focusing in an 800 µm thick tissue-like medium. To show the utility of the model, the focusing was repeated in different conditions illustrative of simplified PAWS experiments involving different spatial resolutions. As expected, a finer spatial resolution led to a brighter focus. By providing a simulation platform for studying PAWS, this work could pave the way to developing systems that can focus light in tissue.

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M3 - Conference contribution

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T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photons Plus Ultrasound

A2 - Oraevsky, Alexander A.

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PB - SPIE

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Y2 - 28 January 2023 through 2 February 2023

ER -

Bewick JAJ, Munro PRT, Arridge SR, Guggenheim JA. A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping. In Oraevsky AA, Wang LV, editors, Photons Plus Ultrasound: Imaging and Sensing 2023. SPIE. 2023. 123790D. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2656075

A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping

Abstract

Publication series

Conference

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Projects

Wavefront shaping for next-generation biomedical photoacoustic imaging

Cite this