A comprehensive analysis of chromosomal polymorphic variants on reproductive outcomes after intracytoplasmic sperm injection treatment

Madara S B Ralapanawe*, Sugandika L Gajaweera, Nishendra Karunaratne, Vajira H W Dissnayake, Malcolm J Price, Pedro Melo, Arri Coomarasamy, Ioannis D Gallos

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Recent studies suggest that chromosomal polymorphic variations are associated with infertility. A systematic review of chromosomal polymorphisms in assisted reproduction found an association with higher rates of miscarriage. Aim of this study is to analyse the influence of specific types or number of chromosomal polymorphic variations on reproductive outcomes of couples undergoing ICSI treatment. We analysed data from 929 fresh and frozen embryo transfer cycles of 692 women who underwent karyotyping analysis using Giemsa-Trypsin-Leishman (GTL) banding prior to the ICSI procedure at the Fertility Centre of Lanka Hospitals Corporation Plc, Sri Lanka, from January 2016 to December 2018. The outcomes of interest were the pregnancy, miscarriage and live birth rate per cycle. There was no evidence of a difference in the reproductive outcomes between carriers or non-carriers of any type or number of chromosomal polymorphic variation. Our data, in contrast to previous studies, does not support a deleterious effect for the type or number of chromosomal polymorphic variations on reproductive outcomes. However, additional prospective, adequately powered studies, conducted in multiethnic populations, are required to further investigate whether the detection of chromosomal polymorphic variants prior to assisted conception may in fact be a futile diagnostic tool.

Original languageEnglish
Article number1319
Number of pages9
JournalScientific Reports
Volume13
Issue number1
DOIs
Publication statusPublished - 24 Jan 2023

Bibliographical note

© 2023. The Author(s).

Keywords

  • Pregnancy
  • Male
  • Female
  • Humans
  • Sperm Injections, Intracytoplasmic/methods
  • Abortion, Spontaneous
  • Prospective Studies
  • Semen
  • Embryo Transfer/methods
  • Fertilization in Vitro
  • Pregnancy Rate
  • Retrospective Studies
  • Live Birth
  • Article
  • /631/208
  • article
  • /692/699/2732/1577

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