TY - JOUR
T1 - A comparison of plasma versus histologic indices of angiogenic markers in breast cancer
AU - Caine, Graham
AU - Lip, Gregory
AU - Zanetto, U
AU - Maheshwari, M
AU - Stonelake, Paul
AU - Blann, Andrew
PY - 2007/12/1
Y1 - 2007/12/1
N2 - BACKGROUND: Over-expression of angiogenic growth factors and their receptors, and high levels of these molecules in the blood, are a common feature of cancer although the relationships between cell expression and plasma levels are unknown. We hypothesized a significant correlation between the expression and cellular distribution of vascular endothelial growth factor (VEGF), its receptor Flt-1, and the angiopoietin receptor Tie-2 with levels of these molecules in the plasma. METHODS: The tissue expression of VEGF, Flt-1, and Tie-2 were investigated by immunohistochemistry, and plasma levels assessed by enzyme-linked immunosorbent assay in 36 patients with breast cancer and 15 with benign breast disease. RESULTS: Despite expected significant differences in plasma levels of the molecules (P
AB - BACKGROUND: Over-expression of angiogenic growth factors and their receptors, and high levels of these molecules in the blood, are a common feature of cancer although the relationships between cell expression and plasma levels are unknown. We hypothesized a significant correlation between the expression and cellular distribution of vascular endothelial growth factor (VEGF), its receptor Flt-1, and the angiopoietin receptor Tie-2 with levels of these molecules in the plasma. METHODS: The tissue expression of VEGF, Flt-1, and Tie-2 were investigated by immunohistochemistry, and plasma levels assessed by enzyme-linked immunosorbent assay in 36 patients with breast cancer and 15 with benign breast disease. RESULTS: Despite expected significant differences in plasma levels of the molecules (P
U2 - 10.1097/01.pai.0000213137.01536.ca
DO - 10.1097/01.pai.0000213137.01536.ca
M3 - Article
C2 - 18091379
SN - 1533-4058
VL - 15
SP - 382
EP - 388
JO - Applied Immunohistochemistry & Molecular Morphology
JF - Applied Immunohistochemistry & Molecular Morphology
IS - 4
ER -
