A Comparison of Phenotypic and Functional Properties of Mesenchymal Stromal Cells and Multipotent Adult Progenitor Cells.

RS Khan; PN Newsome

doi:10.3389/fimmu.2019.01952

A Comparison of Phenotypic and Functional Properties of Mesenchymal Stromal Cells and Multipotent Adult Progenitor Cells.

RS Khan, PN Newsome

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

183 Downloads (Pure)

Abstract

Both Multipotent Adult Progenitor Cells and Mesenchymal Stromal Cells are bone-marrow derived, non-haematopoietic adherent cells, that are well-known for having immunomodulatory and pro-angiogenic properties, whilst being relatively non-immunogenic. However, they are phenotypically and functionally distinct cell types, which has implications for their efficacy in different settings. In this review we compare the phenotypic and functional properties of these two cell types, to help in determining which would be the superior cell type for different applications.

Original language	English
Article number	1952
Journal	Frontiers in immunology
Volume	10
DOIs	https://doi.org/10.3389/fimmu.2019.01952
Publication status	Published - 28 Aug 2019

Keywords

multipotent adult progenitor cell
cellular therapy
mesenchymal stromal cell
immunomodulation
cell biology

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10.3389/fimmu.2019.01952Licence: Creative Commons: Attribution (CC BY)

Khan_Newsome_2020_A_comparison_of_phenotypic_and_functional_properties_Frontiers_in_ImmunologyFinal published version, 1.19 MBLicence: Creative Commons: Attribution (CC BY)

The Potential of Multipoint Adult Progenitor Cells as a Novel Therapeutic Strategy in Alcoholic Hepatitis
Newsome, P. (Principal Investigator) & Lalor, T. (Co-Investigator)
Medical Research Council
1/04/19 → 31/08/23
Project: Research Councils

Cite this

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abstract = "Both Multipotent Adult Progenitor Cells and Mesenchymal Stromal Cells are bone-marrow derived, non-haematopoietic adherent cells, that are well-known for having immunomodulatory and pro-angiogenic properties, whilst being relatively non-immunogenic. However, they are phenotypically and functionally distinct cell types, which has implications for their efficacy in different settings. In this review we compare the phenotypic and functional properties of these two cell types, to help in determining which would be the superior cell type for different applications.",

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AB - Both Multipotent Adult Progenitor Cells and Mesenchymal Stromal Cells are bone-marrow derived, non-haematopoietic adherent cells, that are well-known for having immunomodulatory and pro-angiogenic properties, whilst being relatively non-immunogenic. However, they are phenotypically and functionally distinct cell types, which has implications for their efficacy in different settings. In this review we compare the phenotypic and functional properties of these two cell types, to help in determining which would be the superior cell type for different applications.

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KW - cellular therapy

KW - mesenchymal stromal cell

KW - immunomodulation

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A Comparison of Phenotypic and Functional Properties of Mesenchymal Stromal Cells and Multipotent Adult Progenitor Cells.

Abstract

Keywords

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The Potential of Multipoint Adult Progenitor Cells as a Novel Therapeutic Strategy in Alcoholic Hepatitis

Cite this