A common variant associated with prostate cancer in European and African populations

Laufey T Amundadottir; Patrick Sulem; Julius Gudmundsson; Agnar Helgason; Adam Baker; Bjarni A Agnarsson; Asgeir Sigurdsson; Kristrun R Benediktsdottir; Jean-Baptiste Cazier; Jesus Sainz; Margret Jakobsdottir; Jelena Kostic; Droplaug N Magnusdottir; Shyamali Ghosh; Kari Agnarsson; Birgitta Birgisdottir; Louise Le Roux; Adalheidur Olafsdottir; Thorarinn Blondal; Margret Andresdottir; Olafia Svandis Gretarsdottir; Jon T Bergthorsson; Daniel Gudbjartsson; Arnaldur Gylfason; Gudmar Thorleifsson; Andrei Manolescu; Kristleifur Kristjansson; Gudmundur Geirsson; Helgi Isaksson; Julie Douglas; Jan-Erik Johansson; Katarina Bälter; Fredrik Wiklund; James E Montie; Xiaoying Yu; Brian K Suarez; Carole Ober; Kathleen A Cooney; Henrik Gronberg; William J Catalona; Gudmundur V Einarsson; Rosa B Barkardottir; Jeffrey R Gulcher; Augustine Kong; Unnur Thorsteinsdottir; Kari Stefansson

doi:10.1038/ng1808

A common variant associated with prostate cancer in European and African populations

Laufey T Amundadottir
, Patrick Sulem
, Julius Gudmundsson
, Agnar Helgason
, Adam Baker
, Bjarni A Agnarsson
, Asgeir Sigurdsson
, Kristrun R Benediktsdottir
, Jean-Baptiste Cazier
, Jesus Sainz
, Margret Jakobsdottir
, Jelena Kostic
, Droplaug N Magnusdottir
, Shyamali Ghosh
, Kari Agnarsson
, Birgitta Birgisdottir
, Louise Le Roux
, Adalheidur Olafsdottir
, Thorarinn Blondal
, Margret Andresdottir

Olafia Svandis Gretarsdottir, Jon T Bergthorsson, Daniel Gudbjartsson, Arnaldur Gylfason, Gudmar Thorleifsson, Andrei Manolescu, Kristleifur Kristjansson, Gudmundur Geirsson, Helgi Isaksson, Julie Douglas, Jan-Erik Johansson, Katarina Bälter, Fredrik Wiklund, James E Montie, Xiaoying Yu, Brian K Suarez, Carole Ober, Kathleen A Cooney, Henrik Gronberg, William J Catalona, Gudmundur V Einarsson, Rosa B Barkardottir, Jeffrey R Gulcher, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

590 Citations (Scopus)

Abstract

With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.

Original language	English
Pages (from-to)	652-8
Number of pages	7
Journal	Nature Genetics
Volume	38
Issue number	6
DOIs	https://doi.org/10.1038/ng1808
Publication status	Published - Jun 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

African Continental Ancestry Group
Alleles
European Continental Ancestry Group
Humans
Male
Microsatellite Repeats
Polymorphism, Single Nucleotide
Prostatic Neoplasms

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10.1038/ng1808

Cite this

Amundadottir, L. T., Sulem, P., Gudmundsson, J., Helgason, A., Baker, A., Agnarsson, B. A., Sigurdsson, A., Benediktsdottir, K. R., Cazier, J.-B., Sainz, J., Jakobsdottir, M., Kostic, J., Magnusdottir, D. N., Ghosh, S., Agnarsson, K., Birgisdottir, B., Le Roux, L., Olafsdottir, A., Blondal, T., ... Stefansson, K. (2006). A common variant associated with prostate cancer in European and African populations. Nature Genetics, 38(6), 652-8. https://doi.org/10.1038/ng1808

@article{af07217086fa491a9c6b6b6d8cf9d556,

title = "A common variant associated with prostate cancer in European and African populations",

abstract = "With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19\% of affected men and 13\% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8\%. The association was also replicated in an African American case-control group with a similar OR, in which 41\% of affected individuals and 30\% of the population are carriers. This leads to a greater estimated PAR (16\%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.",

keywords = "African Continental Ancestry Group, Alleles, European Continental Ancestry Group, Humans, Male, Microsatellite Repeats, Polymorphism, Single Nucleotide, Prostatic Neoplasms",

author = "Amundadottir, \{Laufey T\} and Patrick Sulem and Julius Gudmundsson and Agnar Helgason and Adam Baker and Agnarsson, \{Bjarni A\} and Asgeir Sigurdsson and Benediktsdottir, \{Kristrun R\} and Jean-Baptiste Cazier and Jesus Sainz and Margret Jakobsdottir and Jelena Kostic and Magnusdottir, \{Droplaug N\} and Shyamali Ghosh and Kari Agnarsson and Birgitta Birgisdottir and \{Le Roux\}, Louise and Adalheidur Olafsdottir and Thorarinn Blondal and Margret Andresdottir and Gretarsdottir, \{Olafia Svandis\} and Bergthorsson, \{Jon T\} and Daniel Gudbjartsson and Arnaldur Gylfason and Gudmar Thorleifsson and Andrei Manolescu and Kristleifur Kristjansson and Gudmundur Geirsson and Helgi Isaksson and Julie Douglas and Jan-Erik Johansson and Katarina B{\"a}lter and Fredrik Wiklund and Montie, \{James E\} and Xiaoying Yu and Suarez, \{Brian K\} and Carole Ober and Cooney, \{Kathleen A\} and Henrik Gronberg and Catalona, \{William J\} and Einarsson, \{Gudmundur V\} and Barkardottir, \{Rosa B\} and Gulcher, \{Jeffrey R\} and Augustine Kong and Unnur Thorsteinsdottir and Kari Stefansson",

year = "2006",

month = jun,

doi = "10.1038/ng1808",

language = "English",

volume = "38",

pages = "652--8",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "6",

}

Amundadottir, LT, Sulem, P, Gudmundsson, J, Helgason, A, Baker, A, Agnarsson, BA, Sigurdsson, A, Benediktsdottir, KR, Cazier, J-B, Sainz, J, Jakobsdottir, M, Kostic, J, Magnusdottir, DN, Ghosh, S, Agnarsson, K, Birgisdottir, B, Le Roux, L, Olafsdottir, A, Blondal, T, Andresdottir, M, Gretarsdottir, OS, Bergthorsson, JT, Gudbjartsson, D, Gylfason, A, Thorleifsson, G, Manolescu, A, Kristjansson, K, Geirsson, G, Isaksson, H, Douglas, J, Johansson, J-E, Bälter, K, Wiklund, F, Montie, JE, Yu, X, Suarez, BK, Ober, C, Cooney, KA, Gronberg, H, Catalona, WJ, Einarsson, GV, Barkardottir, RB, Gulcher, JR, Kong, A, Thorsteinsdottir, U & Stefansson, K 2006, 'A common variant associated with prostate cancer in European and African populations', Nature Genetics, vol. 38, no. 6, pp. 652-8. https://doi.org/10.1038/ng1808

TY - JOUR

T1 - A common variant associated with prostate cancer in European and African populations

AU - Amundadottir, Laufey T

AU - Sulem, Patrick

AU - Gudmundsson, Julius

AU - Helgason, Agnar

AU - Baker, Adam

AU - Agnarsson, Bjarni A

AU - Sigurdsson, Asgeir

AU - Benediktsdottir, Kristrun R

AU - Cazier, Jean-Baptiste

AU - Sainz, Jesus

AU - Jakobsdottir, Margret

AU - Kostic, Jelena

AU - Magnusdottir, Droplaug N

AU - Ghosh, Shyamali

AU - Agnarsson, Kari

AU - Birgisdottir, Birgitta

AU - Le Roux, Louise

AU - Olafsdottir, Adalheidur

AU - Blondal, Thorarinn

AU - Andresdottir, Margret

AU - Gretarsdottir, Olafia Svandis

AU - Bergthorsson, Jon T

AU - Gudbjartsson, Daniel

AU - Gylfason, Arnaldur

AU - Thorleifsson, Gudmar

AU - Manolescu, Andrei

AU - Kristjansson, Kristleifur

AU - Geirsson, Gudmundur

AU - Isaksson, Helgi

AU - Douglas, Julie

AU - Johansson, Jan-Erik

AU - Bälter, Katarina

AU - Wiklund, Fredrik

AU - Montie, James E

AU - Yu, Xiaoying

AU - Suarez, Brian K

AU - Ober, Carole

AU - Cooney, Kathleen A

AU - Gronberg, Henrik

AU - Catalona, William J

AU - Einarsson, Gudmundur V

AU - Barkardottir, Rosa B

AU - Gulcher, Jeffrey R

AU - Kong, Augustine

AU - Thorsteinsdottir, Unnur

AU - Stefansson, Kari

PY - 2006/6

Y1 - 2006/6

N2 - With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.

AB - With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.

KW - African Continental Ancestry Group

KW - Alleles

KW - European Continental Ancestry Group

KW - Humans

KW - Male

KW - Microsatellite Repeats

KW - Polymorphism, Single Nucleotide

KW - Prostatic Neoplasms

U2 - 10.1038/ng1808

DO - 10.1038/ng1808

M3 - Article

C2 - 16682969

SN - 1061-4036

VL - 38

SP - 652

EP - 658

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -

A common variant associated with prostate cancer in European and African populations

Abstract

UN SDGs

Keywords

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