A co-conformationally "topologically" chiral catenane

Arnau Rodríguez-Rubio, Andrea Savoini, Florian Modicom, Patrick Butler, Stephen M. Goldup*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
39 Downloads (Pure)


Catenanes composed of two achiral rings that are oriented (Cnhsymmetry) because of the sequence of atoms they contain are referred to as topologically chiral. Here, we present the synthesis of a highly enantioenriched catenane containing a related but overlooked "co-conformationally ‘topologically' chiral" stereogenic unit, which arises when a bilaterally symmetric Cnvring is desymmetrized by the position of an oriented macrocycle.

Original languageEnglish
Pages (from-to)11927-11932
Number of pages6
JournalJournal of the American Chemical Society
Issue number27
Early online date28 Jun 2022
Publication statusPublished - 13 Jul 2022

Bibliographical note

Funding Information:
S.M.G. thanks the ERC (Agreement No. 724987) for funding and the Royal Society for a Wolfson Research Fellowship (RSWF\FT\180010). P.B. thanks the University of Southampton for a Presidential Scholarship. F.M. thanks the ESPRC for a Doctoral Prize Scholarship (EP/R513325/1).

Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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