Abstract
Brain tissue oxygen saturation, StO2, measured with near-infrared spectroscopy (NIRS) is of great clinical interest as it quantifies the balance between cerebral oxygen supply and demand. Some brain oximeters are based on spatially resolved spectroscopy (SRS), where NIRS data is collected at multiple distances from the light source to estimate a slope of light attenuation against distance. Other use a broadband approach which utilizes derivatives of the absorption spectra to estimate StO2, such as broadband fitting (BF). We describe a novel algorithm, broadband spatially resolved spectroscopy (BB-SRS), for estimating StO2. It is based on comparing the measured slope to a model of the attenuation slope, which depends on the optical properties of tissue. Fitting this model with a least squares fitting procedure recovers parameters describing absorption and scattering; the concentrations of oxy- and deoxy-haemoglobin and hence StO2 and the scattering parameters ß and a describing the exponential dependence of scattering on wavelength. To demonstrate BB-SRS, a broadband spectrum (700 - 1000 nm, step size 2 nm) was simulated in NIRFAST and was analysed with BB-SRS, SRS and BF. The developed BB-SRS algorithm recovered StO2 with a relative error of -9%; the concentration of deoxyhaemoglobin with a relative error of +4%, oxyhaemoglobin -10%. The scattering parameters ß and a were recovered with a relative error of -30% and -2%, respectively. Among the three algorithms, BB-SRS performed with the best relative error.
Original language | English |
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Title of host publication | European Conference on Biomedical Optics, ECBO_2019 |
Publisher | Optica Publishing Group (formerly OSA) |
ISBN (Print) | 9781510628397 |
DOIs | |
Publication status | Published - 2019 |
Event | European Conference on Biomedical Optics, ECBO_2019 - Munich, Netherlands Duration: 23 Jun 2019 → 25 Jun 2019 |
Publication series
Name | Optics InfoBase Conference Papers |
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Volume | Part F142-ECBO 2019 |
ISSN (Electronic) | 2162-2701 |
Conference
Conference | European Conference on Biomedical Optics, ECBO_2019 |
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Country/Territory | Netherlands |
City | Munich |
Period | 23/06/19 → 25/06/19 |
Bibliographical note
Funding Information:This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 675332. IT is supported by The Wellcome Trust, grant 104580/Z/14/Z. GB is supported by the Medical Research Council, grant MR/S003134/1.
Publisher Copyright:
© SPIE-OSA 2019
Keywords
- Brain oximetry
- Broadband
- Near-infrared spectroscopy
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Mechanics of Materials