A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds

James D. Firth; Philip G. E. Craven; Matthew Lilburn; Axel Pahl; Stephen P. Marsden; Adam Nelson

doi:10.1039/C6CC04662B

A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds

James D. Firth
, Philip G. E. Craven
, Matthew Lilburn
, Axel Pahl
, Stephen P. Marsden
, Adam Nelson

Chemistry

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels–Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.

Original language	English
Pages (from-to)	9837-9840
Journal	Chemical Communications
Volume	52
Issue number	63
Early online date	18 Jul 2016
DOIs	https://doi.org/10.1039/C6CC04662B
Publication status	E-pub ahead of print - 18 Jul 2016

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10.1039/C6CC04662BLicence: Creative Commons: Attribution-NonCommercial (CC BY-NC)

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title = "A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds",

abstract = "A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels–Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.",

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AU - Marsden, Stephen P.

AU - Nelson, Adam

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AB - A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels–Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.

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A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds

Abstract

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