A 7-d exercise program increases high-molecular weight adiponectin in obese adults

Karen R Kelly, Alecia Blaszczak, Jacob M Haus, Aimee Patrick-Melin, Ciaran E Fealy, Thomas P J Solomon, Michael I Kalinski, John P Kirwan

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


PURPOSE: High-molecular weight (HMW) adiponectin is the biologically active form of adiponectin and is related to enhanced insulin sensitivity and metabolic function. Previously, we found that 7 d of exercise improves insulin sensitivity in obese subjects; however, whether short-term exercise training affects HMW adiponectin in obese persons is unknown.

METHODS: We examined the effect of seven consecutive days of supervised vigorous exercise (60 min · d(-1), 85% HRmax) on HMW adiponectin and leptin secretion in 17 obese individuals (age = 55 ± 3 yr; body mass index = 33.7 ± 0.9 kg · m(-2)). Insulin sensitivity was calculated from an oral glucose tolerance test (ISIOGTT) using the Matsuda Index. Fasting plasma HMW adiponectin and leptin were quantified from blood samples obtained before the ISIOGTT. Glucose and insulin measures were obtained before and every 30 min during the test. Dual-energy x-ray absorptiometry was used to determine body composition, and indirect calorimetry was used to assess fat oxidation.

RESULTS: After the intervention, there was a significant increase in HMW adiponectin (3202 ± 543 vs 3878 ± 682 ng · mL(-1), P = 0.02) and a decrease in leptin (36.8 ± 5.1 vs 31.1 ± 4.2 μg · mL(-1), P = 0.03). Further, we observed an increase in ISIOGTT (1.7 ± 0.3 vs 2.1 ± 0.3, P = 0.04) and a decrease in glucose area under the curve (30,871 ± 2105 vs 28,469 ± 1657 mg · dL(-1) for 3 h, P = 0.01). The increase in HMW adiponectin was positively associated with the increase in basal fat oxidation (r = 0.57, P = 0.03), consistent with an improvement in adipose tissue metabolic function.

CONCLUSIONS: The data suggest that 7 d of exercise is sufficient not only to improve insulin sensitivity and fat oxidation but also to favorably alter adipokine secretion, independent of changes in body weight or composition.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalMedicine and Science in Sports and Exercise
Issue number1
Publication statusPublished - Jan 2012


  • Adiponectin
  • Adipose Tissue
  • Blood Glucose
  • Body Composition
  • Exercise
  • Fats
  • Female
  • Glucose Tolerance Test
  • Heart Rate
  • Humans
  • Insulin
  • Insulin Resistance
  • Leptin
  • Male
  • Middle Aged
  • Obesity


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