2-O-Alkylated para-benzamide α-helix mimetics: The role of scaffold curvature

Valeria Azzarito; Panchami Prabhakaran; Alice I. Bartlett; Natasha S. Murphy; Michaele J. Hardie; Colin A. Kilner; Thomas A. Edwards; Stuart L. Warriner; Andrew J. Wilson

doi:10.1039/c2ob26262b

2-O-Alkylated para-benzamide α-helix mimetics: The role of scaffold curvature

Valeria Azzarito
, Panchami Prabhakaran
, Alice I. Bartlett
, Natasha S. Murphy
, Michaele J. Hardie
, Colin A. Kilner
, Thomas A. Edwards
, Stuart L. Warriner
, Andrew J. Wilson^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

The design and synthesis of a new 2-O-alklyated benzamide α-helix mimetic is described. Comparison with regioisomeric 3-O-alkylated benzamides permits a preliminary evaluation of the role that mimetic curvature has in determining molecular recognition properties.

Original language	English
Pages (from-to)	6469-6472
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	32
DOIs	https://doi.org/10.1039/c2ob26262b
Publication status	Published - 28 Aug 2012

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1039/c2ob26262b

Cite this

@article{f1d3beb0130b492383830d85cb36dcb1,

title = "2-O-Alkylated para-benzamide α-helix mimetics: The role of scaffold curvature",

abstract = "The design and synthesis of a new 2-O-alklyated benzamide α-helix mimetic is described. Comparison with regioisomeric 3-O-alkylated benzamides permits a preliminary evaluation of the role that mimetic curvature has in determining molecular recognition properties.",

author = "Valeria Azzarito and Panchami Prabhakaran and Bartlett, \{Alice I.\} and Murphy, \{Natasha S.\} and Hardie, \{Michaele J.\} and Kilner, \{Colin A.\} and Edwards, \{Thomas A.\} and Warriner, \{Stuart L.\} and Wilson, \{Andrew J.\}",

year = "2012",

month = aug,

day = "28",

doi = "10.1039/c2ob26262b",

language = "English",

volume = "10",

pages = "6469--6472",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "32",

}

TY - JOUR

T1 - 2-O-Alkylated para-benzamide α-helix mimetics

T2 - The role of scaffold curvature

AU - Azzarito, Valeria

AU - Prabhakaran, Panchami

AU - Bartlett, Alice I.

AU - Murphy, Natasha S.

AU - Hardie, Michaele J.

AU - Kilner, Colin A.

AU - Edwards, Thomas A.

AU - Warriner, Stuart L.

AU - Wilson, Andrew J.

PY - 2012/8/28

Y1 - 2012/8/28

N2 - The design and synthesis of a new 2-O-alklyated benzamide α-helix mimetic is described. Comparison with regioisomeric 3-O-alkylated benzamides permits a preliminary evaluation of the role that mimetic curvature has in determining molecular recognition properties.

AB - The design and synthesis of a new 2-O-alklyated benzamide α-helix mimetic is described. Comparison with regioisomeric 3-O-alkylated benzamides permits a preliminary evaluation of the role that mimetic curvature has in determining molecular recognition properties.

UR - https://www.scopus.com/pages/publications/84864450122

U2 - 10.1039/c2ob26262b

DO - 10.1039/c2ob26262b

M3 - Article

C2 - 22785578

AN - SCOPUS:84864450122

SN - 1477-0520

VL - 10

SP - 6469

EP - 6472

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 32

ER -

2-O-Alkylated para-benzamide α-helix mimetics: The role of scaffold curvature

Abstract

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this